ALKBH8 suppresses oxidative stress and ameliorates inflammation via blocking NFκB/NLRP3 axis in Sepsis
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ABSTRACT:
PROVIDER: PRJNA869559 | ENA |
REPOSITORIES: ENA
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Project description:The molecular mechanisms underlying sepsis pathogenesis and its regulation are incompletely understood. Here we demonstrated that human AlkB homologue, ALKBH8, plays a critical role in sepsis. we demonstrated that inhibition of Reactive oxygen species (ROS) production by using N-acetylcysteine (NAC) antagonized the effect of ALKBH8 knockdown on inflammation response and NFκB/NLRP3 signaling activation in THP-1 cells.
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