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Opposing transcriptional circuits governing skeletal muscle development and maturation revealed at single nuclear resolution [snATAC-seq]

ABSTRACT: Opposing transcriptional circuits governing skeletal muscle development and maturation revealed at single nuclear resolution [snATAC-seq]

PROVIDER: PRJNA870875 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21120552.fastq.gz	Fastqsanger.gz
	SRR21120552_1.fastq.gz	Fastqsanger.gz
	SRR21120552_2.fastq.gz	Fastqsanger.gz
	SRR21120553.fastq.gz	Fastqsanger.gz
	SRR21120553_1.fastq.gz	Fastqsanger.gz

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Opposing transcriptional circuits governing skeletal muscle development and maturation revealed at single nuclear resolution [snATAC-seq]

Project description:To explore the mechanistic basis of the different phases of pre- and postnatal muscle development and the contraction-dependent control of muscle gene expression , we generated a multi-omics single nucleus RNAseq (snRNA-seq) and single nucleus ATAC-seq (snATAC-seq) atlas of normal muscle and paralyzed muscle from mice lacking Cacna1s.

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Opposing transcriptional circuits governing skeletal muscle development and maturation revealed at single nuclear resolution.

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Opposing transcriptional circuits governing skeletal muscle development and maturation revealed at single nuclear resolution [snRNA-seq]

Project description:Opposing transcriptional circuits governing skeletal muscle development and maturation revealed at single nuclear resolution [snRNA-seq]

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Opposing transcriptional circuits governing skeletal muscle development and maturation revealed at single nuclear resolution [ChIP-seq]

Project description:Opposing transcriptional circuits governing skeletal muscle development and maturation revealed at single nuclear resolution [ChIP-seq]

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Opposing transcriptional circuits governing skeletal muscle development and maturation revealed at single nuclear resolution [snRNA-seq]

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Opposing transcriptional circuits governing skeletal muscle development and maturation revealed at single nuclear resolution.

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-05-31 | GSE211545 | GEO

Opposing transcriptional circuits governing skeletal muscle development and maturation revealed at single nuclear resolution [ChIP-seq]

Project description:During the maturation of myofibers, the expression and activity of the basic leucine zipper TF Maf are increased compared to developmental stages. To determine the gene program regulated by this TF, we performed ChIP-seq against Maf and H3K27ac in adult gastrocnemius and quadriceps skeletal muscles.

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Coordinated excitatory and inhibitory circuits governing unpredictable threat induced anxiety

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Coordinated excitatory and inhibitory circuits governing unpredictable threat induced anxiety

Project description:Anxiety is elicited by excessive apprehension about unpredictable threats. However, the neural circuit governing unpredictable threat induced anxiety remains unclear. Here, we found ventral bed nucleus of the stria terminalis (vBNST) GABAergic neurons displayed selective activation to unpredictable threats by means ofthrough coordinated excitatory input from insular cortex (IC) glutamergic neurons and inhibitory input from lateral nucleus of the amygdala (CeL) somatostatin (SOM) neurons. Using activity-dependent neuronal tagging technology, we found that unpredictable threat responsive cells in vBNST drive freezing and anxiety via projections to ventral lateral periaqueductal grey (vlPAG) and median nucleus of the amygdala (CeM) respectively. Finally, we identified KCNQ3 plays an essential role in hyperactivity of vBNST GABAergic neurons and induced anxiety. These data identified a forward inhibitory circuit that determine the selective activation of vBNST in unpredictable threat and anxiety, and suggest that Kcnq3 KCNQ3 channel acts as a promising target in treatment of anxiety disorder following unpredictable stress.

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snATAC-seq of the developing mouse cerebellum across eleven stages

Project description:This study used droplet-based snATAC-seq to profile the chromatin accessibility landscape of 91,922 nuclei in the mouse cerebellum across eleven developmental stages, from the beginning of neurogenesis (e10.5) till adulthood (P63). The study included two biological replicates per stage, one from each sex. Cerebelli were dissected as whole or in two halves, nuclei were extracted and profiled using 10x single-cell ATAC reagent kit (v1.0) and a Chromium controller. Libraries were sequenced using paired-reads on Illumina NextSeq 550 and initial data processing was performed using Cellranger ATAC (1.1).

2021-09-07 | E-MTAB-9765 | biostudies-arrayexpress

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