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Akkermansia muciniphila blunts Th17 cells

ABSTRACT: Akkermansia muciniphila blunts Th17 cells

PROVIDER: PRJNA870937 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21131000_1.fastq.gz	Fastqsanger.gz
	SRR21131000_2.fastq.gz	Fastqsanger.gz
	SRR21131001_1.fastq.gz	Fastqsanger.gz
	SRR21131001_2.fastq.gz	Fastqsanger.gz
	SRR21131002_1.fastq.gz	Fastqsanger.gz

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Akkermansia muciniphila blunts Th17 cells [Colonic lymphocytes]

Project description:Akkermansia muciniphila blunts Th17 cells [Colonic lymphocytes]

| PRJNA884634 | ENA

Akkermansia muciniphila blunts Th17 cells

Project description:DSS-induced colitis mice were treated with PBS, A. muciniphila secreting extracellular vesicles (SEV) via gavage every day. mice colon tissues from each of the indicated group (Ctrl, Colitis and SEV) in (b) were collected. Mice colon tissues were submitted for scRNA-seq.

2023-01-01 | GSE211578 | GEO

Akkermansia muciniphila blunts Th17 cells [Colonic lymphocytes]

Project description:DSS-induced colitis mice were treated with PBS, A. muciniphila secreting extracellular vesicles (SEV) via gavage every day. Mice lymphocytes of colon tissues from each of the indicated group (Colitis and SEV) in were collected. Then CD4+ T cells are isolated from lymphocytes. These cells were submitted for scRNA-seq.

2022-12-31 | GSE214253 | GEO

Akkermansia muciniphila SEV-containing proteins smaller than 30 kDa

Project description:Histone lysine lactylation (Klac) is a new posttranslational modification (PTM) that is installed by acetyltransferase to modulate specific immune responses1 and oncogenesis2,3. Akkermansia muciniphila (A. muciniphila) is a beneficial bacterium that blunts ulcerative colitis (UC) in a mouse model by secreting extracellular vesicles (SEVs)4. Although many histone sites are known to contain lysine lactylation, whether this modification is regulated to modulate specific biological functions by exogenous acetyltransferase or intestinal microbiota is not well understood. Here, we discovered that SEV from A. muciniphila, rather than A. muciniphila per se, has anti-Th17 (T helper 17) differentiation activity. We further screened the composition of SEV and found that Amuc_2172 is the key active component. As a GCN5-related acetyltransferase of A. muciniphila, Amuc_2172 is accessible to naïve T cells and functions as a lactylation transferase on Lys4 of histone H3. Accelerated histone H3 lactylation (H3Klac) on Lys4 competitively blocks trimethylation (H3Kme3) on Il17a loci in the process of Th17-cell differentiation. Additionally, intraperitoneal application of recombinant Amuc_2172 also inhibited Th17 and dextran sulfate sodium (DSS)-induced UC phenotypes in vivo; moreover, bioengineered Amuc_2172 showed improved colitis site delivery and higher Th17 inhibition potential compared to Amuc_2172 alone. Our study reveals not only a potential therapeutic strategy for treating colitis but also a model via which lysine lactylation is regulated by the intestinal microbiota, which may be broadly applicable to understand the crosstalk of bacteria and immunity.

2023-11-28 | PXD037100 | Pride

Akkermansia muciniphila

Project description:Akkermansia muciniphila overview

| PRJNA36235 | ENA

Akkermansia muciniphila proteome.

Project description:Akkermansia muciniphila, a common member of the human gut microbiota, is considered to be a beneficial resident of the intestinal mucus layer. Surface-exposed molecules produced by this organism likely play important roles in colonization and communication with other microbes and the host, but the protein composition of the outer membrane has not been characterized thus far. Herein we identify A. muciniphila proteins after enrichment and fractionation of the outer membrane proteome of A. muciniphila.

2016-09-27 | PXD004400 | Pride

Akkermansia muciniphila

Project description:Akkermansia muciniphila Genome sequencing

| PRJNA1145077 | ENA

Akkermansia muciniphila

Project description:Akkermansia muciniphila Genome sequencing

| PRJNA921972 | ENA

Akkermansia muciniphila Membrane Protein Improves Cognitive Function in Aged Mice by Reducing IL-6 Expression

Project description:We implemented transcriptomic analyses of blood and hippocampus of old mice treated with Akkermansia muciniphila Membrane Protein for 8 weeks.

2023-08-25 | GSE162123 | GEO

Sequencing of total RNA in mouse ileum to evaluate effect of IFNg and Akkermansia muciniphila on host gene expression

Project description:Total RNA from ileum of three groups of mice are sequenced. The three groups are 1. wild type mice. 2. mice with IFNg gene knockout. 3. IFNg gene knockout mice after colonization of Akkermansia muciniphila

2015-06-05 | E-MTAB-3633 | biostudies-arrayexpress

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