Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Inflammation-associated changes in transcriptomics signature in wild-type and Selenow knock-out murine bone marrow-derived macrophages (BMDMs).

ABSTRACT: Inflammation-associated changes in transcriptomics signature in wild-type and Selenow knock-out murine bone marrow-derived macrophages (BMDMs).

PROVIDER: PRJNA871298 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR21144000.fastq.gz	Fastqsanger.gz
	SRR21144001.fastq.gz	Fastqsanger.gz
	SRR21144002.fastq.gz	Fastqsanger.gz
	SRR21144003.fastq.gz	Fastqsanger.gz
	SRR21144004.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 23

Similar Datasets

Inflammation-associated changes in transcriptomics signature in wild-type and Selenow knock-out murine bone marrow-derived macrophages (BMDMs).

Project description:To investigate differential gene expression profile in Selenow knock-out BMDMs to elucidate the role of this small selenoprotein involving LPS-induced inflammation.

2022-12-28 | GSE211683 | GEO

Gene-expression data of (WT) and knock-out (KO) bone marrow derived macrophages (BMDMs) from C57BL/7 mice

Project description:We provide gene expression data of wild-type (WT) and various knock-out (KO) bone marrow derived macrophages (BMDMs) from mice (C57BL/6) in different conditions of infections and treatments. We included BMDMs from WT (female and male), Ifnar-/-, IFNg-/-, iNOs-/-, Nlrx1-/- (female and male), Nox2-/- and Prx5-/- mice. BMDMs were either infected with a human protozoan parasite Leishmania guyanensis with or without its endosymbiant double-stranded RNA (dsRNA) virus, Leishmania RNA Virus 1 (LgyLRV1+ and LgyLRV1-, respectively). Alternatively BMDMs were treated with a TLR3 agonist poly I:C, a TLR2 agonist FSL1, with H2O2 or tBHQ.

2022-04-20 | GSE201066 | GEO

Gene-expression data of female wild-type (WT) and knock-out (KO) bone marrow derived macrophages (BMDMs) from C57BL/7 mice

Project description:Leishmania are medically relevant protozoan parasites that cause leishmaniasis, a neglected tropical disease that can differently manifest depending on the species and the immune status of the host. Previously, it has been suggested that the presence of an endosymbiont double stranded RNA virus, Leishmania RNA Virus 1 (LRV1), within the parasite may leed to an exarcerbation of the disease outcome and represents an important factor for treatment failure and relapse. Here, we provide gene expression data of wild-type (WT) and various knock-out (KO) bone marrow derived macrophages (BMDMs) from mice (C57BL/6) in different conditions of infections and treatments. We included BMDMs from WT, Ifnar-/-, IFNg-/-, iNOs-/-, Nlrx1-/-, Nox2-/- and Prx5-/- mice. BMDMs were either infected with a human protozoan parasite Leishmania guyanensis with or without its endosymbiant dsRNA virus, LRV1 (LgyLRV1+ and LgyLRV1-, respectively). Alternatively BMDMs were treated with poly I:C, a synthetic dsRNA or a TLR2 agonist FSL1 to identify virus dependetn pathways or to explore the impact of co-exposure to additional agents, respectively.

2022-04-20 | GSE201120 | GEO

Cop1 wildtype and knock out ChIP-seq for CEBPb, H3K4me3 and H3K27ac in BMDMs

Project description:Cop1 wildtype and knock out ChIP-seq for CEBPb, H3K4me3 and H3K27ac in BMDMs

| PRJNA615367 | ENA

Gene-expression data of (WT) and knock-out (KO) bone marrow derived macrophages (BMDMs) from C57BL/7 mice

Project description:Gene-expression data of (WT) and knock-out (KO) bone marrow derived macrophages (BMDMs) from C57BL/7 mice

| PRJNA828177 | ENA

GPS2 cistrome analysis in BMDMs and RAW264.7 cells and epigenome comparison between WT and GPS2-knockout BMDMs.

Project description:GPS2 binding sites in BMDMs can be localized specially in enhancers (H3K27ac) and promoters (H3K27ac, H3K4me3). Upon GPS2 knock-out in BMDMs, de-repression of certain inflammatory genes occur, as accompanied by increased recruitment of H3K27ac and H3K4me3 marks.

2016-06-06 | GSE66774 | GEO

Gene expression signature of DHTKD1 gene knock-out spinal cord

Project description:We employed whole genome microarray expression profiling as a discovery platform to identify gene expression changes after DHTKD1 knock-out RNAs of spinal cords of 8-weeks-old wild-type (n=3) and DHTKD1 knock-out mice (n=3) were used to identify gene expression.

2022-09-12 | GSE81735 | GEO

Next Generation Sequencing Facilitates Quantitative Analysis of control, SETD6 Knock-out, SETD3 knock-out and SETD6+SETD3 knock-out HeLa cells Transcriptomes

Project description:Next Generation Sequencing Facilitates Quantitative Analysis of control, SETD6 Knock-out, SETD3 knock-out and SETD6+SETD3 knock-out HeLa cells Transcriptomes

| PRJNA819059 | ENA

Interleukin-16-knock-out bone-marrow derived macrophages response to Escherichia coli lipopolysaccharide (LPS)

Project description:We have employed whole genome microarray expression profiling to identify differently expressed genes following stimulation of interleukin-16-knock-out bone-marrow derived macrophages with Escherichia coli lipopolysaccharide (LPS). Macrophages were stimulated with LPS (100 ng/ml) for 6 hours and a signature was identified that distinguished between infected and control samples. Expression of several genes from this signature was quantified in the same RNA samples by real-time PCR, confirming the predicted macrophage response pattern.

2010-10-08 | GSE20208 | GEO

Transcriptome analysis of bone marrow in Phc2 knock out mice

Project description:This study investigated the biological function of Phc2 by Phc2 knock out mice. Polycomb group (PcG) proteins function as transcriptional repressors of target genes by mainly modulating histone methylation. The canonical Polycomb repressor complex 1 (PRC1), type of PcG proteins, recognizes and binds to H3K27me3 to sustain the transcriptional repression of a target gene. To investigate the function of canonical PRC1, We identified potential function of Phc2 that is component of the canonical PRC1 by Phc2 knock out mice.

2019-07-10 | GSE128705 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data