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Transcriptomic differences in CCR10+ versus CCR10- regulatory T cells (Tregs)

ABSTRACT: Transcriptomic differences in CCR10+ versus CCR10- regulatory T cells (Tregs)

PROVIDER: PRJNA872344 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21227311_1.fastq.gz	Fastqsanger.gz
	SRR21227311_2.fastq.gz	Fastqsanger.gz
	SRR21227312_1.fastq.gz	Fastqsanger.gz
	SRR21227312_2.fastq.gz	Fastqsanger.gz
	SRR21227313_1.fastq.gz	Fastqsanger.gz

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Transcriptomic differences in CCR10+ versus CCR10- regulatory T cells (Tregs)

Project description:We identified decreases in circulating CCR10+ Tregs in human hypertension. In order to better determine the phenotype of these cells, we performed bulk RNA sequencing of flow sorted human CCR10+ versus CCR10- Tregs from healthy control individuals. Results revealed evidence of increased T cell activation in CCR10+ Tregs.

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Project description:Donminant negative transform growth factor receptor II (DNR) mice were served as a murine primary biliary cirrhrosis model. CD4+Foxp3+ Regulatory T cells (Tregs) play a critical role in self-tolerance and in regulating PBC. In order to determine whether DNR mice derived Tregs processed defective function compared with WT Tregs, CD4+Foxp3+ Treg cells were sorted from DNR and WT mice, respectively, then gene expression analysis was performed by using the Affymetrix GeneChip Mouse Genome 430 2.0 arrays CD4+Foxp3+ Tregs were sorted from the spleen of 10-week-old DNR mice and B6 wild-type mice, respectively. RNA of each sample was then extracted and hybridized on Affymetrix microarrays to detail differences between DNR Tregs and WT Tregs in gene expression.

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