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The role HOXA5 in extrahepatic cholangiocarcinoma (Methylation)

ABSTRACT: The role HOXA5 in extrahepatic cholangiocarcinoma (Methylation)

PROVIDER: PRJNA872545 | ENA |

REPOSITORIES: ENA

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The role HOXA5 in extrahepatic cholangiocarcinoma (Methylation)

Project description:Homeobox A5 (HOXA5) is a transcription factor in mammalian and can regulate cell differentiation, proliferation and apoptosis as well as tumorigenesis. However, little is known on whether and how HOXA5 can regulate the malignant behaviors of cholangiocarcinoma. The methylation levels of HOXA5 were evaluated by methylation microarray and bisulfite sequencing PCR. We found that hypermethylation in the HOXA5 promoter down-regulated HOXA5 expression in extrahepatic cholangiocarcinoma (ECCA) tissues, which was correlated with worse overall survival. HOXA5 over-expression significantly inhibited the proliferation and tumor growth.

2022-10-05 | GSE211911 | GEO

The role HOXA5 in extrahepatic cholangiocarcinoma

Project description:The role HOXA5 in extrahepatic cholangiocarcinoma

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The role HOXA5 in extrahepatic cholangiocarcinoma (Expression)

Project description:The role HOXA5 in extrahepatic cholangiocarcinoma (Expression)

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Project description:Homeobox A5 (HOXA5) is a transcription factor in mammals and can regulate cell differentiation, proliferation and apoptosis as well as tumorigenesis. However, little is known about whether and how HOXA5 can regulate the malignant behaviors of cholangiocarcinoma. The expression profiles were analyzed by RNA microarray. We found MXD1 was upregulated upon HOXA5 overexpression. Besides, p53 pathway was activated by HOXA5 overexpression.

2022-10-05 | GSE211907 | GEO

The binding pattern of HOXA5 in the genome of extrahepatic cholangiocarcinoma cells

Project description:HOXA5 is a transcription factor in mammalian and can regulate cell differentiation, proliferation and apoptosis as well as tumorigenesis. However, little is known on whether and how HOXA5 can regulate the malignant behaviors of cholangiocarcinoma. The binding pattern of HOXA5 was evaluated by CUT & Tag assay. The differential peaks were analysed to assess the role of HOXA5 in the regulation of the key genes involved in cell proliferation and DNA replication.

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The binding pattern of HOXA5 in the genome of extrahepatic cholangiocarcinoma cells

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Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma

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Project description:We examined the transcriptome from bile duct tissue in mice with extrahepatic cholangiocarcinoma

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The role HOXA5 in extrahepatic cholangiocarcinoma

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-10-05 | GSE211912 | GEO