Activation-induced cell death of ILC2s via TIGIT suppresses chronic airway allergy
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA874421 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR21278700_1.fastq.gz | Fastqsanger.gz | |||
| SRR21278700_2.fastq.gz | Fastqsanger.gz | |||
| SRR21278701_1.fastq.gz | Fastqsanger.gz | |||
| SRR21278701_2.fastq.gz | Fastqsanger.gz | |||
| SRR21278702_1.fastq.gz | Fastqsanger.gz |
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Project description:TIGIT+ Tregs suppress Th1 and Th17 responses while sparing Th2 responses. Analysis of global gene expression of TIGIT+ vs. TIGIT- Tregs from naive mice reveled that TIGIT+ Tregs display an activated phenotype and are enriched for Treg signature genes including the Treg effector molecule Fgl2 which enables them to selectively spare Th2 responses.
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