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Transcriptional and epigenetic dysregulation impairs generation of proliferative neural stem and progenitor cells during brain aging

ABSTRACT: Transcriptional and epigenetic dysregulation impairs generation of proliferative neural stem and progenitor cells during brain aging

PROVIDER: PRJNA877006 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21426810.fastq.gz	Fastqsanger.gz
	SRR21426811.fastq.gz	Fastqsanger.gz
	SRR21426812.fastq.gz	Fastqsanger.gz
	SRR21426813.fastq.gz	Fastqsanger.gz
	SRR21426814.fastq.gz	Fastqsanger.gz

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Transcriptional and epigenetic dysregulation impairs generation of proliferative neural stem and progenitor cells during brain aging

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Project description:To study the role of MLL complex in transcriptional dysregulation of NSC aging, we performed ChIP-seq of MLL complex subunits (Kmt2d, Rbbp5, and Wdr5) and Cbx3 in young and aged NSCs to analyze their binding activity at promoters of age-dependent genes.

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