Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A Pan-Cancer Single Cell Panorama of Natural Killer Cells

ABSTRACT: A Pan-Cancer Single Cell Panorama of Natural Killer Cells

PROVIDER: PRJNA877828 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

A Pan-Cancer Single Cell Panorama of Natural Killer Cells

Project description:Natural killer (NK) cells play indispensable roles in innate immune responses against tumor progression, but their phenotypic and functional diversities in the tumor microenvironment (TME) remain unclear. Here, we performed integrated analyses on the single-cell RNA sequencing (scRNA-seq) data for NK cells across multiple cancer types. Our study provides new insights into NK cell–based cancer immunity and highlights the potential clinical utilities of NK cell subsets as therapeutic targets.

2023-08-22 | GSE212890 | GEO

Single-cell RNA sequencing and single-cell CRISPR screens of interacting natural killer and blood cancer cells

Project description:To profile the cell states of interacting natural killer (NK) cells and blood cancer cells, we cultured 26 different cell lines representing diverse hematologic neoplasms either alone or with NK cells derived from three healthy human donors. After 24 h co-culture, we labeled the cells from each monoculture or co-culture condition with oligonucleotide-conjugated antibodies against ubiquitously expressed surface proteins (with different oligonucleotide for each mono- or co-culture), enabling multiplexing in the scRNA-seq using the cell hashing method. We additionally performed pooled CRISPR screens with a single-cell transcriptome readout using the CROP-seq platform in blood cancer cells cultured either alone or in the presence of NK cells to study the effects of perturbing genes that influenced sensitivity to NK cell killing in genome-scale CRISPR screens.

2023-07-24 | E-MTAB-13204 | biostudies-arrayexpress

Expression profiling of Natural killer B cells

Project description:Investigation of global gene expression levels between B cells, Natural killer cells and Natural killer B cells Gene expression profiling using sorted B cells, Natural killer cells and Natural killer B cells from WT mouse spleen. Total RNA extracted from WT cells were quantified by the NanoDrop ND-1000 and RNA integrity was assessed by standard denaturing agarose gel electrophoresis. The sample preparation and microarray hybridization were performed based on the NimbleGenâs standard protocols.

2016-05-17 | E-GEOD-80063 | biostudies-arrayexpress

Expression profiling of Natural killer B cells

Project description:Investigation of global gene expression levels between B cells, Natural killer cells and Natural killer B cells

2016-05-17 | GSE80063 | GEO

Transcription profiling of neonatal and adult mouse natural killer cells

Project description:Comparing global gene expression of neonatal and adult natural killer cells to determine if differences in gene expression suggest that different developmental pathways during hematopoiesis are followed in the fetal and adult mouse to produce mature natural killer cells.

2005-10-01 | E-MEXP-354 | biostudies-arrayexpress

High-activity Natural Killer Immunotherapy for Small Metastases of Colorectal Cancer

Project description:The aim of this study is the safety and efficacy of high-activity natural killer immunotherapy to small metastases of colorectal cancer.

| 2233269 | ecrin-mdr-crc

miRNA expression in mature natural killer cell subsets

Project description:The expression of 800 miRNAs in three human matura natural killer cell subsets was measured.

2017-11-03 | GSE106469 | GEO

RUNX2-specific human Natural Killer (NK) cells

Project description:RUNX2-specific human Natural Killer (NK) cells

| PRJNA723303 | ENA

Natural Killer Cell Therapies for Hematologic Malignancies

Project description:Natural Killer Cell Therapies for Hematologic Malignancies

| PRJNA776383 | ENA

Natural Killer Cell Therapies for Hematologic Malignancies

Project description:Natural Killer Cell Therapies for Hematologic Malignancies