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Transcription profiling of neonatal and adult mouse natural killer cells

ABSTRACT: Comparing global gene expression of neonatal and adult natural killer cells to determine if differences in gene expression suggest that different developmental pathways during hematopoiesis are followed in the fetal and adult mouse to produce mature natural killer cells.

ORGANISM(S): Mus musculus

SUBMITTER: Chelsea Greenwood

PROVIDER: E-MEXP-354 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression of rearranged TCRgamma genes in natural killer cells suggests a minor thymus-dependent pathway of lineage commitment.

Veinotte Linnea Lora LL Greenwood Chelsea Pamela CP Mohammadi Nastaran N Parachoniak Christine Anna CA Takei Fumio F

Blood 20051129 7

Natural killer (NK) cells are thought to develop from common lymphoid progenitors in the bone marrow. However, immature thymocytes also retain NK potential. Currently, the contribution of the thymus-dependent pathway in normal steady-state NK-cell development is unknown. Here, we show that TCRgamma genes are rearranged in approximately 5% of neonatal and 1% of adult mouse splenic NK cells, and similar levels are detected in NK cells from TCRbeta,delta double-knockout mice, excluding the possibil ...[more]

PMID: 16317098

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