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Genome-wide maps of Argonaute 2-chromosome interactions in miR-204-3p-overexpressed macrophages [ChIP-Seq]

ABSTRACT: Genome-wide maps of Argonaute 2-chromosome interactions in miR-204-3p-overexpressed macrophages [ChIP-Seq]

PROVIDER: PRJNA878491 | ENA |

REPOSITORIES: ENA

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Genome-wide maps of Argonaute 2-chromosome interactions in miR-204-3p-overexpressed macrophages [ChIP-Seq]

Project description:Ago2, an essential effector for miRNA function, has been reported to be found in the nucleus together with miRNA. The miRNA-Ago complexes in the nucleus play an important role in regulating gene transcription. We previously have demonstrated the nuclear presence of miR-204-3p in macrophages. Here, we investigated and compared the Ago2 occupancy on the chromosomes upon miR-204-3p overexpression.

2022-09-13 | GSE212935 | GEO

Genome-wide maps of chromatin state changes in miR-204-3p-overexpressed human monocyte-derived macrophages (HMDMs)

Project description:We compared histone modification states between miRNA-204-3p and mimics negative control transfected HMDMs through ChIP. sequencing

2020-12-04 | GSE162599 | GEO

Transcriptomic analysis of miR-204-3p-overexpressed human monocyte-derived macrophages (HMDMs)

Project description:HMDMs were transfected with miRNA mimics negative control or miRNA-204-3p mimics for 24 hours, and then were sequenced to determine gene expression profiles.

2021-02-03 | GSE166049 | GEO

Transcriptomic analysis of miR-204-3p-overexpressed human monocyte-derived macrophages (HMDMs)

Project description:Transcriptomic analysis of miR-204-3p-overexpressed human monocyte-derived macrophages (HMDMs)

| PRJNA699045 | ENA

Genome-wide maps of chromatin state changes in miR-204-3p-overexpressed human monocyte-derived macrophages (HMDMs)

Project description:Genome-wide maps of chromatin state changes in miR-204-3p-overexpressed human monocyte-derived macrophages (HMDMs)

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RNA-seq analysis of mouse bone marrow-derived macrophages overexpressing miR-204-3p

Project description:Bone marrow-derived macrophages were transfected with miRNA-204-3p mimics or mimics negative control for 24 hours. RNA-seq was performed to compare miR-204-3p overexpression versus control cells.

2023-03-01 | GSE223129 | GEO

MiR-204-3p inhibits the production of TLR4-related cytokines in familial Mediterranean fever by targeting the PI3Kγ signaling pathway

Project description:Our data suggest that serum miR-204-3p has a potential as a useful biomarker among patients with FMF and that miR-204-3p plays a critical role as a suppressor to regulate the production of TLR4-related cytokines by targeting PI3K signaling pathway.

2017-06-01 | GSE98940 | GEO

RNA-seq analysis of mouse bone marrow-derived macrophages overexpressing miR-204-3p

Project description:RNA-seq analysis of mouse bone marrow-derived macrophages overexpressing miR-204-3p

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MicroRNA-24-3p is overexpressed in Hodgkin lymphoma and protects Hodgkin and Reed-Sternberg cells from apoptosis [ChIP-chip]

Project description:Micro (mi)RNAs not only play important roles in biological processes such as proliferation, metabolism, differentiation and apoptosis, but also in diseases such as cancers. We identified miRNAs with deregulated expression in Hodgkin lymphoma (HL) and investigated their role in the pathogenesis of HL. Small RNA sequencing revealed 84 significantly differentially expressed miRNAs in HL cell lines as compared to GC-B cells. Three upregulated miRNAs, miR-23a-3p, miR-24-3p and miR-27a-3p, were derived from one primary-miRNA transcript. Loss-of-function analysis for these miRNAs and their seed family members resulted in decreased growth upon miR-24-3p inhibition in three and of miR-27a/b-3p inhibition in one HL cell line. Apoptosis analysis indicated that the effect of miR-24-3p on cell growth is at least in part caused by an increase of apoptotic cells. Argonaute 2 (Ago2)-IP revealed 1,142 genes consistently targeted by miRNAs in at least three out of four HL cell lines. Furthermore, 52 out of the 1,142 genes were predicated targets of miR-24-3p. Functional annotation analysis revealed a function related to cell growth, cell death and/or apoptosis for 15 out of the 52 genes. Western blotting of the top-5 genes showed increased protein levels upon miR-24-3p inhibition for CDKN1B and MYC. In summary, we showed that miR-24-3p is upregulated in HL and its inhibition impaired cell growth possibly via targeting CDKN1B and MYC.

2017-02-26 | GSE92615 | GEO

MIR-204 target genes

Project description:The aim of this study is to discover genes regulated by miR-204. Differential gene expression in HEK-293 cells transfected with miR-204-mimic compared to HEK-293 cells transfected with control oligo (HEK-293 control) was analyzed using the Agilent Human Whole Genome 4x44K gene expression array (Agilent Technologies, Santa Clara, CA). HEK-293 cells were transfected with either miR-204 or a control, and gene expression was analyzed using the Agilent Human Whole Genome 4x44K array. A dye-swap was performed.

2012-03-30 | E-GEOD-28400 | biostudies-arrayexpress

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