Project description:Interventions: 1. Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS);
2. Colonoscopy.
Primary outcome(s): Investigate whether DWIBS is effective for colorectal cancer screening.
Study Design: N/A: single arm study, Single blinded (masking used), N/A , unknown, Crossover
Project description:This datasets contain the proteomes relative to the whole body protein extract and to the chemically discharged nematocysts of the white gorgonian Eunicella singularis (Octocorallia) to investigate its venom composition.
Project description:We used isotopic (heavy) labelling to delineate between female and male proteins interacting in the female reproductive tract. Here, we test the efficiency of the labelling protocols on the whole body of males and females.
Project description:Sponges (Porifera) are early-branching Metazoa who do not posess muscles or neurons, however are able to undergo a whole-body movement that involves the closure of their canal system and collapse of an epithelial tent. In this study we profile proteomic responses of the freshwater sponge Spongilla lacustris during agitation induced movements to elucidate the early evolution of coordination. Results from Thermal Proteome Profiling (TPP) experiments of agitated sponges suggest active secretion during the movement. Here, we use tandem mass tag (TMT) labeling-based quantification of proteins in the medium to systematically measure quantitative differences of secretion before and after agitation induced movement. In total, 146 proteins were detected in the medium, 47 of which were significantly upregulated during the movement.