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Transcriptome data of bone marrow long-term hematopoietic stem cells (LT-HSCs) from mice with or without 3-month high cholesterol diet (HCD) treatment

ABSTRACT: Transcriptome data of bone marrow long-term hematopoietic stem cells (LT-HSCs) from mice with or without 3-month high cholesterol diet (HCD) treatment

PROVIDER: PRJNA883663 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21684143_1.fastq.gz	Fastqsanger.gz
	SRR21684143_2.fastq.gz	Fastqsanger.gz
	SRR21684144_1.fastq.gz	Fastqsanger.gz
	SRR21684144_2.fastq.gz	Fastqsanger.gz
	SRR21684145_1.fastq.gz	Fastqsanger.gz

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Transcriptome data of bone marrow long-term hematopoietic stem cells (LT-HSCs) from mice with or without 3-month high cholesterol diet (HCD) treatment

Project description:The vulnerability of bone marrow hematopoiesis to perturbations of cholesterol metabolism is well documented, while the underlying cellular and molecular mechanisms remain poorly understood. Here we reveal a distinct cholesterol metabolic signature of hematopoietic stem cells (HSCs) within the hematopoietic compartment.To identify the phenotype switching and function variation in BM LT-HSCs with HCD treatment, we performed RNA-seq of LT-HSCs from the bone marrow of mice with or without3-month HCD treatment.

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Project description:Loss of Phf6 prevents the functional decline and immunophenotypic changes associated with age-related, long-term repopulating hematopoietic stem cell (LT-HSC) exhaustion. To identify the underlying molecular mechanisms that account for these differences, we performed RNA-seq profiling of LT-HSCs isolated from the bone marrow of Phf6 wild-type and knock-out, young (16-week-old) and aged (24-month-old) C57BL/6 mice. Our analysis revealed that LT-HSCs isolated from 24-month-old, Phf6 knockout mice retained the molecular signatures associated with young LT-HSCs whereas LT-HSCs isolated from aged, Phf6 wild-type mice acquired signatures consistent with HSC exhaustion. Mechanistically, these data revealed important roles for key metabolic pathways including glutathione metabolism and sterol biosynthesis, as well as cell-cell interaction and signaling pathways such as the interferon and TGF-beta responses.

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Project description:The vulnerability of bone marrow hematopoiesis to perturbations of serine metabolism as well as the underlying cellular and molecular mechanisms remain poorly understood. Here we reveal a distinct serine metabolic signature of hematopoietic stem cells (HSCs) within the hematopoietic compartment.To identify the phenotype switching and function variation in BM LT-HSCs with SGFD treatment, we performed RNA-seq of LT-HSCs from the bone marrow of mice with or without3-month SGFD treatment.

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RNA Seq of 7-month old control and Cyp26b1KO LT-HSCs

Project description:The transcriptome of Ctrl and Cyp26b1KO longterm hematopoietic stem cells (LT-HSC) of 7-month old mice was assessed by RNAseq.

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Gene expression profiling of LT-HSCs and ST-HSCs conditionally expressing MLL-ENL

Project description:We have developed a new conditional transgenic mouse showing that MLL-ENL, at an endogenous-like expression level, induces leukemic transformation selectively in LT-HSCs. To investigate the molecular mechanism of leukemic transformation in LT-HSCs conditionally expressing MLL-ENL, we preliminarily performed comprehensive gene expression profiling of CreER-transduced LT-HSCs and ST-HSCs using cDNA microarray analysis. For initial screening of candidate genes invloved in the leukemic transformation, total RNA was extracted from colony-forming cells derived from LT-HSCs and ST-HSCs transduced with CreER or mock. Four samples were analyzed, and CreER-transduced LT/ST-HSC-derived cells were compared with mock-transduced LT/ST-HSC-derived cells, while CreER/mock-transduced LT-HSC-derived cells were compared with CreER/mock-transduced ST-HSC-derived cells.

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Gene expression profiling of LT-HSCs and ST-HSCs conditionally expressing MLL-ENL

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