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Epigenome-wide association analysis of pancreatic exocrine cells from High Fat dietary and normal dietary mice.

ABSTRACT: Epigenome-wide association analysis of pancreatic exocrine cells from High Fat dietary and normal dietary mice.

PROVIDER: PRJNA883665 | ENA |

REPOSITORIES: ENA

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Epigenome-wide association analysis of pancreatic exocrine cells from High Fat dietary and normal dietary mice.

Project description:Genomo wide DNA methylation analysis of isolated pancreatic exocrine cells from high fat dietary and normal dietary mice. The illumima Infinium MethylationEPIC was used to obtain DNA methylatoin profiles across approximately 287K CpGs in isolated cultured cells. Total twelve samples (seven controls and five obese cases) were included in the file.

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Project description:The purpose of the current study was to use an epigenome-wide association approach (EWAS) to identify a potential DNA methylation alterations associated with obesity using twins discordant on obesity status. Buccal cells (from a cheek swab) were used as a purified marker cell for the epigenetic analysis. Analysis of differential DNA methylation regions (DMRs) was used to identify epigenetic associations with metabolic and dietary measures in obesity parameters discordant twins. An edgeR analysis provided a DMR signature with p<1e-04, but a false discovery rate analysis demonstrated a lack of significance due to low sample size and known multivariant origins of obesity.

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