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Molecular analysis of platinum-resistant and -sensitive ovarian cacner based on RNA-Seq analysis

ABSTRACT: Molecular analysis of platinum-resistant and -sensitive ovarian cacner based on RNA-Seq analysis

PROVIDER: PRJNA884836 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21728621_1.fastq.gz	Fastqsanger.gz
	SRR21728621_2.fastq.gz	Fastqsanger.gz
	SRR21728622_1.fastq.gz	Fastqsanger.gz
	SRR21728622_2.fastq.gz	Fastqsanger.gz
	SRR21728623_1.fastq.gz	Fastqsanger.gz

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Molecular analysis of platinum-resistant and -sensitive ovarian cacner based on RNA-Seq analysis

Project description:Ovarian cancer (OC) is the leading cause of death from gynecologic malignancies. The most difficult issue in the treatment of ovarian cancer is the eventual development of platinum resistance. Accumulating studies have shown that circRNAs are abnormally aberrantly expressed in tumors and play critical roles in tumor growth, metastasis, stemness and resistance to therapy.To identify circRNAs that play crucial roles in maintaining the platinum resistance of ovarian cacner, we performed RNA-seq analysis in platinum-resistant（n=9） and -sensitive（n=10） ovarian cacner tissues. Candidate genes were identified by bioinformatic analysis and literature review.

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