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Gene expression in human corneal epithelial cells (hCECs), human corneal fibroblasts (hCFs) or human corneal endothelial cells (hCEnCs) with or without exosomes derived from hCECs, hCFs or hCEnCs

ABSTRACT: Gene expression in human corneal epithelial cells (hCECs), human corneal fibroblasts (hCFs) or human corneal endothelial cells (hCEnCs) with or without exosomes derived from hCECs, hCFs or hCEnCs

PROVIDER: PRJNA888564 | ENA |

REPOSITORIES: ENA

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Gene expression in human corneal epithelial cells (hCECs), human corneal fibroblasts (hCFs) or human corneal endothelial cells (hCEnCs) with or without exosomes derived from hCECs, hCFs or hCEnCs

Project description:In this study, we evaluated the effects of the corneal exosomes on the gene profiling expression in hCECs, hCFS and hCEnCs

2022-10-10 | GSE215102 | GEO

Gene expression in human corneal epithelial cells without or with Wnk inhibitor

Project description:In the present study, we investigated the molecular mechanisms by which Wnk contributes to human corneal epithelial wound healing. To better understand the process, we cultivated human corneal epithelial cells without or with Wnk inhibitor. Using gene profiling, we compared the mRNA profiles of passage 3 human corneal epithelial cells cultivated without Wnk inhibitor with passage 3 human corneal epithelial cells cultivated with Wnk inhibitor. Human corneal epithelial cells are isolated from eye bank donor corneas.

2021-09-08 | GSE183599 | GEO

Expression data from human corneal endothelial cells

Project description:Human corneal endothelial cells (HCEC) form a monolayer by adhering tightly through their intercellular adhesion molecules. Located at the posterior corneal surface, they maintain corneal translucency by dehydrating the corneal stroma, mainly through the Na+- and K+-dependent ATPase (Na+/K+-ATPase). Because HCEC proliferative activity is low in vivo,we tried to activate proliferation of HCEC by inhibiting cyclin-dependent kinase inhibitors.We have here demonstrated microarray data of transduced human corneal endothelial cell lines. Affymetrix human U133 plus 2.0 array was used to transcriptionally profile to compare cultured human corneal endothelial cells and transduced human corneal endothelial cells.

2011-10-29 | E-GEOD-30781 | biostudies-arrayexpress

Gene expression of human corneal epithelial cells grown with irradiated human fibroblasts or irradiated mouse 3T3 feeder layer .

Project description:human corneal epithelial cells were isolated from healthy human donor eyes. Cells were cultured with irradiated 3T3 (i3T3) murine fibroblast feeder cells, irradiated human corneal fibroblasts (iHFL) or without feeder layer

2019-12-12 | GSE141841 | GEO

Human Corneal Endothelium

Project description:A Transcriptomic Study of Human Corneal Endothelial Cells

| PRJEB33538 | ENA

Expression data from human corneal endothelial cells

2011-10-30 | GSE30781 | GEO

Expression data from human iPSC-derived corneal epithelial cells

Project description:We successfully induced corneal epithelial cells from human iPSCs. Then, we perfomed global expression analysis using microarray to compare the character of hiPSC-derived corneal epithelial cells with that of the other kinds of cells. Total RNA was obtained from human iPSCs (hiPSCs), human iPSC-derived corneal epithelial cells (hiCECs), human corneal limbal epithelial cells (HCECs), human oral keratinocytes (HOKs), human dermal fibroblasts (HDFs) and six weeks-differentiated hiPSCs (hiPSC-derived ocular surface ectoderm, OSE) using the QIAZol reagent. A microarray analysis using Sure Print G3 human 8x60K slides (Agilent technologies) was performed at Takara Bio (Shiga, Japan).

2016-03-09 | E-GEOD-73971 | biostudies-arrayexpress

Human corneal epithelial cells internalize Aspergillus flavus spores by actin mediated endocytosis

Project description:Mycotic leratitis is the corneal inflammation predominantly caused by Fusarium and Aspergillus species. Corneal epithelium is the earliest cell type encounter the invading pathogen. The innate immune responses of human corneal epithelial cells against Aspergillus flavus is not known. Here we studied the role of human corneal epithelial cells against Aspergillus flavus infection. The results showed that corneal epithelial cells internalized Aspergillus flavus conidia through actin mediated polymerization surrounding the conidia. Further the actin inhibitor cytochalasin D treatment reduced the formation actin ring around the conidia. The engulfed conidia acquired endosomal proteins as revealed by immunofluorescence analsyisis. Mass spectromtery of phagosomal proteins confirmed the recruitment of endosomal proteins and other proteins involved in phagocytosis. These results show the involvement of corneal epithelial cells in anti fungal defense.

2021-04-07 | PXD019512 | Pride

Human embryonic stem cell-derived corneal endothelial cells

Project description:Aim: To generate human embryonic stem cell-derived corneal endothelial cells (hESC-CECs) for transplantation in patients with corneal endothelial dystrophies.

2017-02-09 | GSE70954 | GEO

Differentiating human embryonic stem cells into corneal epithelial-like cells

Project description:Transplantation of ex vivo expanded limbal stem cells (LSC) is the main treatment for limbal stem cell deficiency though the clinical problem of donor tissues shortage. Recently, as the development of tissue engineering, embryonic stem cells (ESC) derived corneal epithelial-like cells (ESC-CEC) has become a new direction to this issue.Our group successfully induced ESC into corneal epithelial-like cells, and in the present study we explored various aspects of physiological properties of ESC-CEC. The experiment included three samples: hES, the human embryonic stem cell line H1, RA_SB, the corneal epithelial-like cells derived from hES by differentiation with RA and SB, epithelial_cell, the primary human limbal stem cells from cadaver eyes. hES, the human embryonic stem cell line H1, RA_SB, the corneal epithelial-like cells derived from hES by differentiation with RA and SB, epithelial_cell, the primary human limbal stem cells from cadaver eyes.

2015-06-24 | E-GEOD-70152 | biostudies-arrayexpress

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