Project description:To investigate the signalling pathways affected by SAMHD1 depletion, whole transciptome profiling was performed in WT and in different clones of SAMHD1-KO breast cancer cell line (T47D cells)
Project description:To explore the mechanisms underlying SAMHD1 effect on breast cancer prognosis whole transciptome profiling was performed in WT and in different clones of SAMHD1-KO breast cancer cell line (T47D cells) grown in spheroids. Spheroids represents better the tumor microenvironment.
Project description:Goal: elucidate transcriptomic changes upon knock-out of components of the FERRY complex Methods: RNA extraction from HeLa wildtype and fy-1, fy-2, fy-4 and fy-5 knock-out celllines and subsequent RNASeq Results: We observed differences in the transcriptome of all four knock-out cell lines Conclusions: In the Analysis we focused on genes that were differentially expressed in all four KO cell lines or upon KO of fy-1 and fy-2.
Project description:polyA RNA-seq was performed on different SMCHD1 and LRIF1 knock-out myoblast clones to assess the role of SMCHD1 and LRIF1 in transcriptioanl regulation in somatic cells
Project description:Total RNA sequencing data generated from untreated wild type (NT) and vimentin knock out (KO) mouse hippocampal neural stem cells (NSCs) cultured in vitro
Project description:Gene expression analysis in THP-1 cells with SAMHD1 knockout (KO) compared to THP-1 control cells expressing endogenous SAMHD1 reveals that the expression of more than 1000 genes is significantly affected by SAMHD1.