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C-Myc supports polyploidy and prevents senescence in the murine placenta [scRNA-Seq]

ABSTRACT: c-Myc supports polyploidy and prevents senescence in the murine placenta [scRNA-Seq]

PROVIDER: PRJNA890164 | ENA |

REPOSITORIES: ENA

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c-Myc supports polyploidy and prevents senescence in the murine placenta

Project description:c-Myc supports polyploidy and prevents senescence in the murine placenta

| PRJNA890160 | ENA

c-Myc supports polyploidy and prevents senescence in the murine placenta [RNA-seq]

Project description:c-Myc supports polyploidy and prevents senescence in the murine placenta [RNA-seq]

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c-Myc supports polyploidy and prevents senescence in the murine placenta [scRNA-Seq]

Project description:Placenta is essential for reproductive success and placental abnormalities are the leading cause of low birth weight and preterm birth. The placenta includes polyploid cells that are crucial for its function. Polyploidy occurs broadly in nature but the regulators that enable polyploidy to arise in a spatiotemporally regulated manner in the placenta are unknown. We used scRNA seq to understand molecular regulators of polyploidy.

2023-05-12 | GSE215381 | GEO

c-Myc supports polyploidy and prevents senescence in the murine placenta

Project description:This SuperSeries is composed of the SubSeries listed below.

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c-Myc supports polyploidy and prevents senescence in the murine placenta [RNA-seq]

Project description:To understand differential gene expression between wildtype and c-Myc null mouse trophoblast giant cells.

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BLM deficiency affects cytotoxicity of temozolomide and olaparib against human glioma cells and induces cellular senescence or polyploidy

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Project description:Cell size and biosynthetic capacity generally increase with increased DNA content. Somatic polyploidy has therefore been proposed to be an adaptive strategy to increase cell size in specialized tissues with high biosynthetic demands. However, if and how DNA concentration limits cellular biosynthesis in vivo is not well understood. Here, we show that polyploidy in the C. elegans intestine is critical for cell growth and yolk biosynthesis, a central role of this organ. Artificially lowering the DNA/cytoplasm ratio by reducing polyploidization in the intestine gave rise to smaller cells with dilute mRNA. Highly-expressed transcripts were more sensitive to this mRNA dilution, whereas lowly-expressed genes were partially compensated – in part by loading more RNA Polymerase II on the remaining genomes. Polyploidy-deficient animals produced fewer and slower growing offspring, consistent with reduced synthesis of highly-expressed yolk proteins. DNA-dilute cells had normal total protein concentration, which we propose is achieved by increasing expression of translational machinery at the expense of specialized, cell-type specific proteins.

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Somatic polyploidy supports biosynthesis and tissue function by increasing transcriptional output [RNA-seq]

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Somatic polyploidy supports biosynthesis and tissue function by increasing transcriptional output [ChIP-seq]

Project description:Somatic polyploidy supports biosynthesis and tissue function by increasing transcriptional output [ChIP-seq]

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