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Effects of IL-1b inhibition on the phenotypes of spleen naive CD4+ T (TN) cells.

ABSTRACT: Effects of IL-1b inhibition on the phenotypes of spleen naive CD4+ T (TN) cells.

PROVIDER: PRJNA890602 | ENA |

REPOSITORIES: ENA

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Effects of IL-1b inhibition on the phenotypes of spleen naive CD4+ T (TN) cells.

Project description:To analyze the influence of IL-1b on TN cells, RNA-seq analysis was performed on spleen TN cells from mice treated or not treated with IL-1b inhibitors.

2024-03-01 | GSE215777 | GEO

Effects of mTOR inhibition on the phenotypes of spleen naive CD4+ T (TN) cells.

Project description:Effects of mTOR inhibition on the phenotypes of spleen naive CD4+ T (TN) cells.

| PRJNA971900 | ENA

Comparison of mRNA expression between naive CD4+ T (TN) cells treated or not treated with IL-1b

Project description:To analyze effects of IL-1b on TN cells, RNA-seq analysis was performed on freshly prepared TN cells (0 h) and TN cells cultured with or without recombinamt IL-1b.

2024-03-01 | GSE215776 | GEO

Comparison of mRNA expression between spleen and mesenteric lymph node (mLN) naive CD4+ T (TN) cells

Project description:To analyze difference between spleen and mLN TN cells, RNA-seq analysis was performed on TN cells freshly prepared from each organ.

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RNA-seq analysis of spleen and mesenteric lymph node (mLN) hematopoietic cells

Project description:To search for factors that affect naive CD4+ T (TN) cell phenotypes in spleen, we performed RNA-seq analysis to compare mRNA expression between freshly-prepared spleen and mLN hematopoietic cells.

2024-03-01 | GSE215774 | GEO

Effects of mTOR inhibition on the phenotypes of spleen naive CD4+ T (TN) cells.

Project description:To analyze the influence of mTOR activity on TN cells, RNA-seq analysis was performed on splenic TN cells from mice treated or not treated with the mTOR inhibitor Rapamycin.

2024-02-26 | GSE232385 | GEO

Comparison of mRNA expression between naive CD4+ T (TN) cells treated or not treated with IL-1b

Project description:Comparison of mRNA expression between naive CD4+ T (TN) cells treated or not treated with IL-1b

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Comparison of mRNA expression between spleen and mesenteric lymph node (mLN) naive CD4+ T (TN) cells

Project description:Comparison of mRNA expression between spleen and mesenteric lymph node (mLN) naive CD4+ T (TN) cells

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Elucidation of the effects of tonic TCR stimulation and tissue environments of the chromatin status of naive CD4 T (TN) cells

Project description:Naive CD4 T (TN) cells show some degree of heterogeneity. However, mechanisms that alter TN cells are still largely unknown, and physiological importance in the phenotypic alteration of TN cells is unclear. Thus, to reveal the mechanisms that alter TN cell characteristics, we performed transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) on TN cells from different secondary lymphoid organs with different strength of tonic TCR stimulation.

2024-03-01 | GSE215773 | GEO

EXoO-Tn: Tag-n-Map the Tn Antigen in the Human Proteome

Project description:Tn antigen (Tn), a single N-acetylgalactosamine (GalNAc) monosaccharide attached to protein Ser and Thr residues, is found on most solid tumors yet rarely detected in adult tissues: featuring it one of the most distinctive signatures of cancers. Although it is prevalent in cancers, Tn-glycosylation sites are not entirely clear owing to the lack of suitable technology. Knowing the Tn-glycosylation sites will spur the development of the new vaccines, diagnostics, and therapeutics of cancers. Here, we report a novel technology named EXoO-Tn for large-scale mapping of Tn-glycosylation sites. EXoO-Tn utilizes glycosyltransferase C1GalT1 and isotopically-labeled UDP-Gal(13C6) to tag and convert Tn to Gal(13C6)-Tn. This exquisite Gal(13C6)-Tn structure is recognized by a human-gut-bacterial enzyme, called OpeRATOR, that specifically cleaves N-termini of the Gal(13C6)-Tn-occupied Ser and Thr residues to yield site-containing glycopeptides. The enzymes C1GalT1 and OpeRATOR could be used concurrently in one-pot. The effectiveness of EXoO-Tn was evaluated by analyzing Jurkat cells, where 947 Tn-glycosylation sites from 480 glycoproteins were mapped. Bioinformatic analysis of the identified site-specific Tn-glycoproteins revealed conserved motif, cellular localization, relative position in proteins, and mapped site-specific Tn-glycoproteome in different studies. Given the significance of Tn in cancers, EXoO-Tn is anticipated to have broad utilities in clinical study of cancers.

2022-02-15 | PXD014390 | Pride

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