Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Differential Gene expression after peroxiredoxin2 downregulation in human extravillous cytotrophoblast-derived cell line HTR8

ABSTRACT: Differential Gene expression after peroxiredoxin2 downregulation in human extravillous cytotrophoblast-derived cell line HTR8

PROVIDER: PRJNA890898 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Differential Gene expression after peroxiredoxin2 downregulation in human extravillous cytotrophoblast-derived cell line HTR8

Project description:The study was designed to expolre the differential gene expression after peroxiredoxin2 (Prdx2) downregulation by siRNAs transfection in human trophoblast cell line HTR8 compared with negative control.

2022-10-17 | GSE215845 | GEO

Homo sapiens

Project description:Differential Gene expression after peroxiredoxin2 downregulation in human extravillous cytotrophoblast-derived cell line HTR8

| PRJNA889407 | ENA

RRBS investigation of matched side-population trophoblast, cytotrophoblast and extravillous trophoblast populations from 4 human placentae

Project description:RRBS investigation of matched side-population trophoblast, cytotrophoblast and extravillous trophoblast populations from 4 human placentae

| PRJNA431648 | ENA

Human cytotrophoblast organoids

Project description:Human cytotrophoblast organoid cultures were established from the villous trophoblast of first trimester placentas. We analyzed the global expression profile of the cytotrophoblast organoids (CTB-ORG) and compared to the profile of the tissue of origin i.e. villous cytotrophoblast (vCTB) as well as to differentiated syncytiotrophoblast (STB) and placental fibroblasts (FIB).

2018-08-02 | GSE109976 | GEO

Human cytotrophoblast organoids

Project description:Human cytotrophoblast organoids

| PRJNA432503 | ENA

RRBS investigation of matched side-population trophoblast, cytotrophoblast and extravillous trophoblast populations from 4 human placentae

Project description:To better understand how DNA methylation influences placentation, DNA from first trimester primary trophoblast populations (side-population trophoblasts, cytotrophoblasts and extravillous trophoblasts) isolated using FACS underwent reduced representation bisulfite sequencing and were compared to publicly available data of blastocyst-derived and somatic cell populations.

2018-12-25 | GSE109682 | GEO

Preeclampsia: the in vivo milieu leads to cytotrophoblast dysregulation

Project description:During human pregnancy, placental cytotrophoblasts invade the uterus and its blood vessels, anchoring the progeny and rerouting maternal blood to the embryo/fetus. In preeclampsia, cytotrophoblast invasion is restricted and blood flow to the placenta is reduced. The causes of restricted cytotrophoblast invasion are unknown. Here, preeclampsia and control cytotrophoblasts were cultured for 48 h to allow differentiation/invasion. In various severe forms of preeclampsia Â± intrauterine growth restriction, global transcriptional profiling revealed common aberrations in cytotrophoblast gene expression that resolved with culture. Villous cytotrophoblasts were isolated from preeclampsia placentas (PRE, n=5) and placentas of preterm labor patients without signs of infection (PTL, n=5), which served as gestation-matched controls. To better understand the CTB phenotype in the context of PE variants, we included patients with the most clinically significant forms of this condition that necessitated preterm delivery: women with severe PE Â± intrauterine growth restrictions, PE with superimposed hypertension and HELLP syndrome (hemolysis, elevated liver enzymes; low platelet count). RNA was purified immediately after the cells were isolated (0 h) and after 12, 24 and 48 h in culture. The relative gene expression across the whole genome was profiled using the Affymetrix HG-U133Plus 2.0 GeneChip platform. Array quality was assesed using RMAExpress. One sample of preterm labor collected at 48h was omitted (39 arrays total). We used both LIMMA and maSigPro (R/Bioconductor) to determine differentially expressed genes.

2012-08-17 | E-GEOD-40182 | biostudies-arrayexpress

Trophoblast epithelial-mesenchymal transition (EMT) in abnormally invasive placenta (AIP)

Project description:Comparison of genes associated with the EMT between cytotrophoblast cells (CTB) and extravillous trophoblast cells (EVT) from normal third trimester placenta and abnormally invasive placenta (AIP)

2018-01-01 | GSE104350 | GEO

Transcriptomic analysis of human extravillous trophoblast cells (HTR8/Svneo) cultured as 3D spheroids and 2D monolayers

Project description:Transcriptomic analysis of human extravillous trophoblast cells (HTR8/Svneo) cultured as 3D spheroids and 2D monolayers

| PRJNA523498 | ENA

lncRNA downregulation

Project description:lncRNA downregulation

| PRJEB21799 | ENA