Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mus musculus

ABSTRACT: Single-cell transcriptomics reveals cellular heterogeneity and complex cell-cell communication networks in the mouse cornea

PROVIDER: PRJNA891516 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22076381_1.fastq.gz	Fastqsanger.gz
	SRR22076381_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

Bulk RNAseq expression data of colon biopsies from intestinal mucosa of non-IBD controls and patients with Crohn's disease or ulcerative colitis

Project description:Ulcerative colitis and Crohn’s disease are chronic inflammatory intestinal diseases with perplexing heterogeneity in manifestations and response to treatment. While the molecular basis for this heterogeneity remains uncharacterized, single-cell technologies allow us to explore the transcriptional states within tissues at an unprecedented resolution which could further understanding of these complex diseases. Here, we apply single-cell RNA-sequencing to human inflamed intestine and show that the largest differences among patients are present within the myeloid compartment including macrophages and neutrophils. Using spatial transcriptomics in human tissue at single-cell resolution (CosMx Spatial Molecular Imaging) we spatially localized each of the macrophage and neutrophil subsets identified by single-cell RNA-sequencing and unravel further macrophage diversity based on their tissue localization. Finally, single-cell RNA-sequencing combined with single-cell spatial analysis reveals a strong communication network involving macrophages and inflammatory fibroblasts. Our data sheds light on the cellular complexity of these diseases and points towards the myeloid and stromal compartments as important cellular subsets for understanding patient-to-patient heterogeneity.

2023-06-20 | GSE235236 | GEO

The human gastrointestinal tract through space and time- Fetal Spatial transcriptomics

Project description:Single-cell RNAseq (scRNAseq) and paired VDJ analysis and spatial transcriptomics, we create the first comprehensive cell atlas of the healthy developing, paediatric and adult human gut, including 347,980 cells from up to 10 distinct anatomical sites. We use this data to trace the cellular composition of the gut throughout life, define novel cell markers and cell-cell interactions. We find four neuronal cell populations in the developing enteric nervous system, with expression patterns indicative of irritable bowel syndrome and Hirschsprung’s disease, and identify key cell players and communication networks initiating lymphoid structure formation in early human development.

2021-04-30 | E-MTAB-10386 | biostudies-arrayexpress

Single-Cell Transcriptomics Shows Cellular Heterogeneity, Intercellular Communication, and Extracellular Matrix Remodeling in Corneal Fibrosis In Vivo

Project description:Single-Cell Transcriptomics Shows Cellular Heterogeneity, Intercellular Communication, and Extracellular Matrix Remodeling in Corneal Fibrosis In Vivo

| PRJNA1292860 | ENA

Single-cell transcriptomics identifies cellular heterogeneity in large skin wounds

Project description:Single-cell transcriptomics identifies cellular heterogeneity in large skin wounds

| PRJNA454278 | ENA

Single-nucleus and Spatial Transcriptomics Reveal Intestinal Cellular Heterogeneity, Differentiation, and Cell Communication Mechanisms in SAP-induced Intestinal Injury [Spatial Transcriptomics]

Project description:Single-nucleus and Spatial Transcriptomics Reveal Intestinal Cellular Heterogeneity, Differentiation, and Cell Communication Mechanisms in SAP-induced Intestinal Injury [Spatial Transcriptomics]

| PRJNA1405731 | ENA

Single Cell Transcriptomics Reveals Dysregulated Cellular and Molecular Networks in a Fragile X Syndrome Model

Project description:Single Cell Transcriptomics Reveals Dysregulated Cellular and Molecular Networks in a Fragile X Syndrome Model

| PRJNA613291 | ENA

Project description:Single-cell transcriptomics reveals cellular heterogeneity of condylar chondrocytes in SD rat temporomandibular joint osteoarthritis

| PRJNA1347984 | ENA

Single-nucleus and Spatial Transcriptomics Reveal Intestinal Cellular Heterogeneity, Differentiation, and Cell Communication Mechanisms in SAP-induced Intestinal Injury

Project description:Single-nucleus and Spatial Transcriptomics Reveal Intestinal Cellular Heterogeneity, Differentiation, and Cell Communication Mechanisms in SAP-induced Intestinal Injury

| PRJNA1405721 | ENA

Transcriptomic and Single-Cell Analysis Reveals Regulatory Networks and Cellular Heterogeneity in Mouse Sjögren’s Syndrome Salivary Glands

Project description:Transcriptomic and Single-Cell Analysis Reveals Regulatory Networks and Cellular Heterogeneity in Mouse Sjögren’s Syndrome Salivary Glands

| PRJNA733146 | ENA

Single-cell transcriptomics reveals microglia heterogeneity across the nigrostriatal pathway

Project description:Single-cell transcriptomics reveals microglia heterogeneity across the nigrostriatal pathway

| PRJNA624131 | ENA