Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data with olfactory neuronal cells from healthy controls and schizophrenia patients

ABSTRACT: Expression data with olfactory neuronal cells from healthy controls and schizophrenia patients

PROVIDER: PRJNA891654 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Expression data with olfactory neuronal cells from healthy controls and schizophrenia patients

Project description:The use of biospecimens sampled from patients with active symptomatic manifestation has been regarded as indispensable for studying pathophysiological mechanisms in many medical conditions, such as several types of cancers, liver disorders encompassing hepatitis, and lung disorders including idiopathic pulmonary fibrosis. However, due to the difficulty in accessing the brain in living patients, this strategy has not been utilized in psychiatry. To overcome this limitation, multiple investigators have recently highlighted the utility of olfactory epithelium-derived neuronal cells (henceforth, ‘olfactory neuronal cells’), easily accessible through a nasal biopsy, as a promising surrogate that captures neuron-relevant molecular signatures in the course of functional impairment in living patients with major psychiatric disorders. We analyzed gene expression profiles of olfactory neuronal cells from patients with schizophrenia compared to those from healthy controls. A microarray analysis identified significantly dysregulated genes in SZ

2022-10-20 | GSE215985 | GEO

miRNA expression in blood of 15 schizophrenia patients and 15 healthy controls

Project description:The study profiles genome-wide miRNA expression in blood from 15 early-onset SZ (EOS) cases and 15 healthy controls. A total of 1070 miRNAs were detected by the microarrays in our samples. We profiles miRNA expression in 15 schizophrenia samples and 15 healthy controls to explore the alteration of miRNAs in schizophrenia.

2014-12-02 | GSE54578 | GEO

Gene expression profiles of patients with schizophrenia, bipolar disorder and healthy controls

Project description:Schizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric conditions, with a lifetime prevalence of about 1%. Both disorders have a neurodevelopment component, with onset of symptoms occurring most frequently during late adolescence or early adulthood. Genetic findings indicate the existence of an overlap in genetic susceptibility across the disorders. These gene expression profiles were used to identify the molecular mechanisms that differentiate SZ and BP from healthy controls but also that distinguish both from healthy individuals. They were also used to expand an analysis from an experiment that searched molecular alterations in human induced pluripotent stem cells derived from fibroblasts from control subject and individual with schizophrenia and further differentiated to neuron to identify genes relevant for the development of schizophrenia (GSE62105). Brain tissue (frontal cortex) from 30 healthy controls, 29 bipolar disorder patients and 29 schizophrenia patients were analyzed. The reference is an in-house pool of RNA extracted from 15 human cell lines.

2014-10-11 | E-GEOD-62191 | biostudies-arrayexpress

Expression in blood of schizophrenia patients and healthy controls

Project description:Expression in blood of schizophrenia patients and healthy controls

| PRJNA238013 | ENA

mRNA expression in blood of 18 schizophrenia patients and 12 healthy controls

Project description:The study profiles genome-wide mRNA expression in blood from 18 early-onset SZ (EOS) cases and 12 healthy controls. A total of 1070 mRNAs were detected by the microarrays in our samples. 18 schizophrenia samples and 12 healthy controls were used to acquire blood expression profiles

2014-12-05 | E-GEOD-54913 | biostudies-arrayexpress

Gene expression profiles of patients with schizophrenia, bipolar disorder and healthy controls

2014-10-11 | GSE62191 | GEO

Molecular signatures associated with cognitive deficits in schizophrenia: a study of biopsied olfactory neural epithelium

Project description:Cognitive deficit is a key feature of schizophrenia (SZ) and determines functional outcome. Nonetheless, molecular signatures underlying the deficit in neuronal tissues are not well understood. We performed microarray analysis of olfactory epithelium (OE) tissues from SZ and control subjects with their neuropsychological assessment data. Furthermore, we examined gene expression profiles of lymphoblasts for the molecular signatures identified in the OE tissues .

2017-06-12 | GSE73129 | GEO

Olfactory cleft proteome does not reflect olfactory performance in patients with idiopathic and postinfectious olfactory disorder: A pilot study.

Project description:The pathophysiology of post-infectious and idiopathic olfactory loss is still poorly delineated. Since proteins are key players in olfaction and technical advances including LC-MS/MS mass spectrometry give us the opportunity for detailed analysis of the nasal mucus proteome we aimed to undertake a comparative analysis of the olfactory cleft mucus proteome using mucus samples of the olfactory cleft in patients with idiopathic and postinfectious olfactory disorders versus healthy controls. The study was conceived as a pilot study and included 7 patients with idiopathic hyp- and anosmia, 7 patients with postinfectious hyp- and anosmia and 7 healthy controls. In total, 1117 different proteins were detected in at least 5 patients in at least one group. No significant different overall protein concentrations in patients compared to healthy controls (0.4614 µg/µL, SD=0.26273 vs. 0.5143 µg/µL, SD=3087; p=0.689) were found. Significant correlation regarding olfactory test results (TDI score) and protein concentrations (r=0.114, p=0.623) were either found. Results of this study did not show significant differences regarding the proteomic composition of the olfactory cleft mucus between patients suffering from postinfectious and idiopathic dysosmia versus healthy controls. Thus, central olfactory processing pathways may play a role in idiopathic and postinfectious olfactory disorders.

2018-12-10 | PXD009172 | Pride

Utilising Psych Arrays for the identification of CNVs and SNPs from Schizophrenia cases and controls from South-India.

Project description:Genotyping data on 192 schizophrenia cases and 181 healthy controls was generated using Psych Array V 1.3 Aim: To identify CNVs and SNPs associated with increased risk of schizophrenia

2024-01-16 | GSE242813 | GEO

Schizophrenia Proteome Data High Resolution Method

Project description:PTM-tolerant quantitative proteome analysis of plasma collected from schizophrenia patients and nonspychiatric healthy controls.

2021-03-02 | MSV000086977 | MassIVE

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data