Project description:Our findings suggest that FtMt serves as a protective function in myocardial infarction by limiting infarct size, reducing the incidence of ventricular arrhythmias, and inhibiting ferroptosis both in vivo and in vitro. Our results also indicate that FtMt could be a promising therapeutic target for myocardial infarction.
Project description:We studied new microRNAs involved in the left ventricular adverse remodeling (LVAR) process after the ST elevation myocardial infarction (STEMI). We analyzed the expression of miRNAs in peripheral blood mononuclear cells (PBMCs) isolated from a group of non-LVAR (n = 5) and LVAR STEMI patients (n = 5), before (0 hour) and after a primary percutaneous coronary intervention (PPCI; 6 hours).