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Primary breast epithelial cells from healthy donor versus its TONSL overexpressing counterpart-enriched gene expression

ABSTRACT: Primary breast epithelial cells from healthy donor versus its TONSL overexpressing counterpart-enriched gene expression

PROVIDER: PRJNA892639 | ENA |

REPOSITORIES: ENA

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Primary breast epithelial cells from healthy donor versus its TONSL overexpressing counterpart-enriched gene expression

Project description:To evaluate the probable role of TONSL during tumorigenesis and to study the TONSL specific transcriptomic changes, we overexpressed TONSL in primary bresat epithelial cells and studied differential gene expression

2023-10-31 | GSE216238 | GEO

Study of differential chromatin accessibility within primary breast epithelial cells from healthy donor and its TONSL overexpressing counterpart

Project description:Study of differential chromatin accessibility within primary breast epithelial cells from healthy donor and its TONSL overexpressing counterpart

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Donor T cells in ovarian graft versus host disease

Project description:Analysis of donor CD4+ and CD8+ T cells purified from spleens and ovaries after murine syngeneic and allogeneic hematopoietic stem cell transplantation Infertility associated with ovarian failure is a serious late complication for female survivors of allogeneic hematopoietic stem cell transplantation (SCT). While the role of pretransplant conditioning regimen has been well appreciated, increasing application of reduced-intensity conditioning facilitated us to revisit the other factors possibly affecting ovarian function after allogeneic SCT. We have addressed whether donor T-cell mediated graft-versus-host disease (GVHD) could be causally related to female infertility in mice. To study transcriptomes of donor T cells infiltrating into the ovary, donor T cells were sorted from recipients' ovaries and microarray analysis was performed.

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RNA-seq of hESCs overexpressing inducible KLF17 versus uninduced controls.

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NTM & Healthy Donor Immunology & Genomics

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NTM & Healthy Donor Immunology & Genomics

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Study of differential chromatin accessibility within primary breast epithelial cells from healthy donor and its TONSL overexpressing counterpart

Project description:To evaluate the probable role of TONSL during tumorigenesis we overexpressed TONSL in primary breast epithelial cells and studied differential chromatin accessibility.

2023-10-31 | GSE216237 | GEO

Prediction of graft-versus-host disease in humans by donor gene expression profiling

Project description:Graft-versus-host disease (GVHD) results from recognition of host antigens by donor T cells following allogeneic hematopoietic cell transplantion (AHCT). Notably, histoincompatibility between donor and recipient is necessary but not sufficient to elicit GVHD. Therefore, we tested the hypothesis that some donors may be “stronger alloresponders” than others, and consequently more likely to elicit GVHD. To this end, we analyzed the gene expression profile of CD4 and CD8 T cells from 50 AHCT donors. We found that pre-AHCT gene expression profiling segregates donors whose recipient suffered from GVHD or not. The “dangerous donor” trait (GVHD+ recipient) is under polygenic control and is shaped by the activity of genes that regulate diverse cell functions including TGF-β signaling and cell proliferation. We also performed gene expression profiling in T cells harvested from 40 AHCT recipients on day 365 post-AHCT. The donor gene profile defined on day 0 showed exceedingly strong correlation with that of recipient CD4 and CD8 T cells harvested one year post-AHCT. These data suggest that donor gene profiles linked with GVHD were largely imprinted at the hematopoietic stem cell level. The ability to discriminate strong and weak alloresponders using gene expression profiling could pave the way to personalized transplantation medicine. Keywords: comparative gene profile, cell type comparaison, GVHD+, GVHD-

2007-03-27 | GSE4624 | GEO

Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Project description:This pilot phase II trial studies how well giving donor T cells after donor stem cell transplant works in treating patients with hematologic malignancies. In a donor stem cell transplant, the donated stem cells may replace the patient’s immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Giving an infusion of the donor’s T cells (donor lymphocyte infusion) after the transplant may help increase this effect.

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Analysis of differentially expressed genes between human Bone Marrow Stromal cells (hBMSC) and relative fully differentiated adipocytes from two healthy donor

Project description:We compared gene expression profiles in human bone Marrow Stromal Cells (hBMSC) from two healthy donor versus fully differentiated adipocytes by microarray analysis in order to identify groups of genes associated with a specific adipocytes secreted molecules.

2018-04-17 | GSE104536 | GEO

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