Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies

ABSTRACT: This pilot phase II trial studies how well giving donor T cells after donor stem cell transplant works in treating patients with hematologic malignancies. In a donor stem cell transplant, the donated stem cells may replace the patient’s immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Giving an infusion of the donor’s T cells (donor lymphocyte infusion) after the transplant may help increase this effect.

DISEASE(S): Recurrent Childhood Small Noncleaved Cell Lymphoma,Blastic Phase Chronic Myelogenous Leukemia,Lymphoma, Large-cell, Immunoblastic,Lymphoproliferative Disorders,Recurrent Childhood Anaplastic Large Cell Lymphoma,Childhood Burkitt Lymphoma,Recurrent Grade 1 Follicular Lymphoma,Leukemia, Hairy Cell,Childhood Immunoblastic Large Cell Lymphoma,Refractory Chronic Lymphocytic Leukemia,Mycosis Fungoides,Previously Treated Myelodysplastic Syndromes,Recurrent Adult Burkitt Lymphoma,Leukemia, T-cell,Lymphomatoid Granulomatosis,De Novo Myelodysplastic Syndromes,Lymphoma, T-cell, Peripheral,Preleukemia,Lymphoma, B-cell, Marginal Zone,Leukemia, Myelogenous, Chronic, Bcr-abl Positive,Nodal Marginal Zone B-cell Lymphoma,Childhood Diffuse Large Cell Lymphoma,Recurrent Small Lymphocytic Lymphoma,Adult Acute Myeloid Leukemia With Inv(16)(p13;q22),Lymphoma, T-cell, Cutaneous,Adult Acute Myeloid Leukemia With Del(5q),Lymphoma, Follicular,Waldenstrom Macroglobulinemia,Leukemia, Myeloid, Accelerated Phase,Recurrent Mantle Cell Lymphoma,Relapsing Chronic Myelogenous Leukemia,Chronic Phase Chronic Myelogenous Leukemia,Recurrent Childhood Acute Lymphoblastic Leukemia,Childhood Chronic Myelogenous Leukemia,Leukemia,Hodgkin Disease,Recurrent Adult Hodgkin Lymphoma,Mycoses,Recurrent Adult Lymphoblastic Lymphoma,Recurrent Childhood Large Cell Lymphoma,Leukemia, Myeloid, Acute,Leukemia, Large Granular Lymphocytic,Testicular Lymphoma,Lymphoma, T-cell,Blast Crisis,Myelodysplastic Syndromes,Recurrent Adult Acute Myeloid Leukemia,Leukemia, Myeloid,Immunoblastic Lymphadenopathy,Recurrent Adult Diffuse Mixed Cell Lymphoma,Recurrent Adult T-cell Leukemia/lymphoma,Lymphoma, Non-hodgkin,Recurrent Adult Diffuse Large Cell Lymphoma,Lymphoma, B-cell,Extranodal Marginal Zone B-cell Lymphoma Of Mucosa-associated Lymphoid Tissue,Lymphoma, Large B-cell, Diffuse,Leukemia, Myeloid, Chronic-phase,Small Intestine Lymphoma,Refractory Hairy Cell Leukemia,Sezary Syndrome,T-cell Large Granular Lymphocyte Leukemia,Adult Nasal Type Extranodal Nk/t-cell Lymphoma,Splenic Marginal Zone Lymphoma,Lymphoma, Mantle-cell,Leukemia-lymphoma, Adult T-cell,Recurrent Adult Immunoblastic Large Cell Lymphoma,Recurrent Childhood Acute Myeloid Leukemia,Recurrent Childhood Lymphoblastic Lymphoma,Lymphoma, Extranodal Nk-t-cell,Plasmablastic Lymphoma,Burkitt Lymphoma,Recurrent Adult Diffuse Small Cleaved Cell Lymphoma,Post-transplant Lymphoproliferative Disorder,Adult Acute Myeloid Leukemia With T(8;21)(q22;q22),Adult Acute Myeloid Leukemia With 11q23 (mll) Abnormalities,Recurrent Marginal Zone Lymphoma,Recurrent Adult Grade Iii Lymphomatoid Granulomatosis,Leukemia, Lymphocytic, Chronic, B-cell,Intraocular Lymphoma,Recurrent Adult Acute Lymphoblastic Leukemia,Recurrent Grade 3 Follicular Lymphoma,Hematologic Neoplasms,Accelerated Phase Chronic Myelogenous Leukemia,Waldenström Macroglobulinemia,Recurrent Childhood Grade Iii Lymphomatoid Granulomatosis,Noncutaneous Extranodal Lymphoma,Angioimmunoblastic T-cell Lymphoma,Lymphoma, Large-cell, Anaplastic,Adult Acute Myeloid Leukemia With T(16;16)(p13;q22),Hepatosplenic T-cell Lymphoma,Secondary Myelodysplastic Syndromes,Leukemia, Lymphoid,Precursor Cell Lymphoblastic Leukemia-lymphoma,Recurrent Cutaneous T-cell Non-hodgkin Lymphoma,Lymphoma,Childhood Nasal Type Extranodal Nk/t-cell Lymphoma,Recurrent Mycosis Fungoides/sezary Syndrome,Childhood Myelodysplastic Syndromes,Anaplastic Large Cell Lymphoma,Recurrent Grade 2 Follicular Lymphoma,Adult Acute Myeloid Leukemia With T(15;17)(q22;q12),Peripheral T-cell Lymphoma,Recurrent/refractory Childhood Hodgkin Lymphoma,Cutaneous B-cell Non-hodgkin Lymphoma

PROVIDER: 2143763 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR