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ABSTRACT: Gene transcription of hESC derived trophoblast 24h after B7-H4/VTCN1 Kockdown

PROVIDER: PRJNA896499 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22225048_1.fastq.gz	Fastqsanger.gz
	SRR22225048_2.fastq.gz	Fastqsanger.gz
	SRR22225049_1.fastq.gz	Fastqsanger.gz
	SRR22225049_2.fastq.gz	Fastqsanger.gz
	SRR22225050.fastq.gz	Fastqsanger.gz

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Project description:Gene transcription of hESC derived trophoblast 48h after B7-H4/VTCN1 Kockdown

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Project description:Gene transcription of hESC derived trophoblast 72h after B7-H4/VTCN1 Kockdown

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The immune checkpoint molecule, B7-H4/VTCN1, guides differentiation and suppresses proinflammatory responses and MHC class I expression in an embryonic stem cell-derived model of primitive human trophoblast III

Project description:VTCN1/B7-H4 is expressed in human embryonic stem cells (hESC) to an in vitro model of primitive trophoblast (TB) and first trimester but not term human placenta and that primitive trophoblast may be uniquely susceptible to certain pathogens.

2023-03-13 | GSE227096 | GEO

2023-03-13 | GSE227095 | GEO

2023-03-13 | GSE227094 | GEO

Microinjection of human ESC-derived trophoblast cells(BAP cells) to mouse blastocysts

Project description:Purpose: 1. Characterize hESCs and hESC-derived trophoblast cells Results: 1. hESCs have high level of most pluripotency markers; 2. hESC-derived trophoblast cells specifically express trophoblast markers.

2024-11-22 | GSE224029 | GEO

Analysis of Wild Type and B7-H4-/- leukemia initial cells Transcriptomes

Project description:The goal of this study are to find the abonormally expressed genes of B7-H4-/- leukemia inital cells in MLL-AF9 induced AML mice by RNA-seq analysis.Methods: Lin- festival liver cells were isolated from WT and B7-H4-null mice and infected with MLL-AF9 retroviruses, then transplanted to the lethally irradiated recipient mice. When AML developed, we isolated the YFP+/Mac-1+/c-Kit+ bone marrow cells by FACS and and then made the RNA-sequence using Illumina. Results: We identified 27180 transcripts in wild type and B7-H4-/- leukemia initial cells. 572 transcripts showed differential expression between the WT and B7-H4−/− LICs, with a fold change ≥1.5 and p value <0.01. 271 transcripts were downregulated and 241 transcripts were upregulated.

2018-10-25 | GSE89161 | GEO

Effect of SOX9 depletion on transcription mRNA in hESC-derived cranial neural crest cells [SLAM-seq]

Project description:To assess the effects of SOX9 depletion on transcription in hESC-derived cranial neural crest cells, we performed genome editing of the H9 hESC lines to tag SOX9 with FKBPV36, V5, and mNeonGreen. Upon differentiating edited hESC to cranial neural crest cells using an established protocol, addition of the degrader molecule dTAGV-1 results in SOX9 depletion. We then profiled transcription by metabolic labeling of RNA (SLAM-Seq) in undepleted CNCCs or CNCCs in which SOX9 was depleted for 3h or 24h

2022-07-04 | GSE205903 | GEO

Genome wide mapping of chromatin binding sites of GATA2, GATA3, TFAP2A, TFAP2C transcription factors in trophoblast progenitors derived from human embryonic stem cells

Project description:Human embryonic stem cells (hESC) can be differentiated into progenitors resembling trophoblast upon exposure to BMP4. Among the earliest transcription factors that are activated after the BMP4 stimulation are GATA2, GATA3, TFAP2A and TFAP2C. Using trophoblast progenitors at day 3 of BMP4-induced differentiation, here we profile the chromatin binding landscape of these 4 early transcription factors to analyse their putative targets and cross-connectivity in regualtion of trophoblast commitment.

2017-10-18 | GSE105081 | GEO

Expression data from APA+ and APA- progenitors and SSEA5+ human pluripotent stem cells

Project description:Human embryonic stem cells (hESC) can be differentiated into progenitors resembling trophoblast upon exposure to BMP4. Putative trophpblast progenitors express APA cell surface marker Using FACS sorting and microarray we analysed the gene expression of APA-positive trophoblast progenitors, APA-negative progenitors and SSEA5-positive undifferentiated hESC and identified genes that contribute to the trophoblast fate

2017-10-12 | GSE104818 | GEO

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