Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [RNA-seq]

ABSTRACT: Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [RNA-seq]

PROVIDER: PRJNA896528 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22127200_1.fastq.gz	Fastqsanger.gz
	SRR22127200_2.fastq.gz	Fastqsanger.gz
	SRR22127201_1.fastq.gz	Fastqsanger.gz
	SRR22127201_2.fastq.gz	Fastqsanger.gz
	SRR22127202_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 60

Similar Datasets

Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity

Project description:Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity

| PRJNA897006 | ENA

Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [Hi-C]

Project description:Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [Hi-C]

| PRJNA897009 | ENA

Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [ChIP-seq]

Project description:Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [ChIP-seq]

| PRJNA958250 | ENA

Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [CUT&TAG]

Project description:Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [CUT&TAG]

| PRJNA896521 | ENA

Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [ChIP-seq]

Project description:Chromatin conformation reorganization is emerging as an important layer of regulation for gene expression and lineage specification. Yet, how lineage-specific transcription factors contribute to the establishment of cell type-specific 3D chromatin architecture in the immune cells remains unclear, especially for the late stages of T cell subset differentiation and maturation. Regulatory T cells (Treg) are mainly generated in the thymus as a subpopulation of T cells specializing in suppressing excessive immune responses. Here, by comprehensively mapping 3D chromatin organization during Treg cell differentiation, we show that Treg-specific chromatin structures were progressively established during its lineage specification, and highly associated with Treg signature gene expression. Additionally, the binding sites of Foxp3, a Treg lineage specifying transcription factor, were highly enriched at Treg-specific chromatin loop anchors. Further comparison of the chromatin interactions between wide-type Tregs versus Treg cells from Foxp3 knock-in/knockout or newly-generated Foxp3 domain-swap mutant mouse revealed that Foxp3 was essential for the establishment of Treg-specific 3D chromatin architecture, although it was not dependent on the formation of the Foxp3 domain-swapped dimer. These results highlighted an underappreciated role of Foxp3 in modulating Treg-specific 3D chromatin structure formation.

2023-06-14 | GSE230330 | GEO