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Gene expression changes in Mettl3-deleted mouse oviduct on gestational day 3

ABSTRACT: Gene expression changes in Mettl3-deleted mouse oviduct on gestational day 3

PROVIDER: PRJNA897849 | ENA |

REPOSITORIES: ENA

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Gene expression changes in Mettl3-deleted mouse oviduct on gestational day 3

Project description:We specifically deleted Mettl3 in the female reproductive tract using the Pgr-Cre driver. To portray the molecular mechanism for Mettl3 function in oviduct, whole oviduct were collected from Mettl3f/f and Mettl3d/d mice on gestational day 3 and subjected to RNA-seq analysis.

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Gene expression changes in Mettl3-deleted mouse uterus on gestational day 4

Project description:We specifically deleted Mettl3 in the female reproductive tract using the Pgr-Cre driver. To portray the molecular mechanism for Mettl3 function in uterus, uterine tissues were collected from Mettl3f/f and Mettl3d/d mice on gestational day 4 and subjected to RNA-seq analysis.

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Gene expression changes in Mettl3-deleted mouse uterus on gestational day 4

Project description:Gene expression changes in Mettl3-deleted mouse uterus on gestational day 4

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Gene expression changes in conditional METTL3 overexpression mouse uterus compared to control mouse uterus on gestational day 8

Project description:We specifically over-expressed Mettl3 in mouse uterus using the Pgr-Cre driver. To portray the molecular mechanism for Mettl3 function in mouse uterus during decidualization, uterine tissues were collected from METTL3-OE and control mice on gestational day 8 and subjected to RNA-seq analysis.

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Gene expression changes in Mettl3ed/ed mouse uterus compared to Mettl3f/f mouse uterus on gestational day 4

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Single-cell RNA-seq analysis of Mettl14d/d mouse uterus compared to Mettl14f/f mouse uterus on gestational day 4

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Neonatal genistein and pregnancy day 2 oviduct gene expression

Project description:Neonatal genistein treatment causes complete infertility in adult mice. Part of their infertility can be attributed to a loss of 50% of the preimplantation embryos during transit through the oviduct between days 2 and 3 of pregnancy. Comparison of the gene expression signatures of oviducts collected on pregnancy day 2 revealed significant alterations in gene expression, particularly in genes involved in development and the inflammatory response. These findings were verified by real time PCR and in some cases at the protein level by immunoblotting or immunohistochemistry.

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Gene expression in Cdc42f/f and PgrCreCdc42f/f mice oviduct

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