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Gene expression changes in Mettl3-deleted mouse oviduct on gestational day 3

ABSTRACT: Gene expression changes in Mettl3-deleted mouse oviduct on gestational day 3

PROVIDER: PRJNA897849 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22175693_1.fastq.gz	Fastqsanger.gz
	SRR22175693_2.fastq.gz	Fastqsanger.gz
	SRR22175694_1.fastq.gz	Fastqsanger.gz
	SRR22175694_2.fastq.gz	Fastqsanger.gz
	SRR22175695_1.fastq.gz	Fastqsanger.gz

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Gene expression changes in Mettl3-deleted mouse oviduct on gestational day 3

Project description:We specifically deleted Mettl3 in the female reproductive tract using the Pgr-Cre driver. To portray the molecular mechanism for Mettl3 function in oviduct, whole oviduct were collected from Mettl3f/f and Mettl3d/d mice on gestational day 3 and subjected to RNA-seq analysis.

2022-11-18 | GSE217174 | GEO

Gene expression changes in Mettl3-deleted mouse uterus on gestational day 4

Project description:We specifically deleted Mettl3 in the female reproductive tract using the Pgr-Cre driver. To portray the molecular mechanism for Mettl3 function in uterus, uterine tissues were collected from Mettl3f/f and Mettl3d/d mice on gestational day 4 and subjected to RNA-seq analysis.

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Gene expression changes in Mettl3-deleted mouse uterus on gestational day 4

Project description:Gene expression changes in Mettl3-deleted mouse uterus on gestational day 4

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Gene expression changes in conditional METTL3 overexpression mouse uterus compared to control mouse uterus on gestational day 8

Project description:We specifically over-expressed Mettl3 in mouse uterus using the Pgr-Cre driver. To portray the molecular mechanism for Mettl3 function in mouse uterus during decidualization, uterine tissues were collected from METTL3-OE and control mice on gestational day 8 and subjected to RNA-seq analysis.

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Gene expression changes in Mettl3ed/ed mouse uterus compared to Mettl3f/f mouse uterus on gestational day 4

Project description:We specifically deleted Mettl3 in the epithelium of mouse uterus using the Ltf-Cre driver. To portray the molecular mechanism for Mettl3 function in uterine epithelium, uterine tissues were collected from Mettl3f/f and Mettl3ed/ed mice on gestational day 4 and subjected to RNA-seq analysis.

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Gene expression changes in Mettl14d/d mouse uterus compared to Mettl14f/f mouse uterus on gestational day 4 [RNA-seq]

Project description:We specifically deleted Mettl14 in mouse uterus using the Pgr-Cre driver. To portray the molecular mechanism for Mettl14 function in mouse uterus, uterine tissues were collected from Mettl14f/f and Mettl14d/d mice on gestational day 4 and subjected to RNA-seq analysis.

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Single-cell RNA-seq analysis of Mettl14d/d mouse uterus compared to Mettl14f/f mouse uterus on gestational day 4

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Gene expression changes in conditional METTL3 overexpression mouse uterus compared to control mouse uterus on gestational day 8

Project description:Gene expression changes in conditional METTL3 overexpression mouse uterus compared to control mouse uterus on gestational day 8

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Neonatal genistein and pregnancy day 2 oviduct gene expression

Project description:Neonatal genistein treatment causes complete infertility in adult mice. Part of their infertility can be attributed to a loss of 50% of the preimplantation embryos during transit through the oviduct between days 2 and 3 of pregnancy. Comparison of the gene expression signatures of oviducts collected on pregnancy day 2 revealed significant alterations in gene expression, particularly in genes involved in development and the inflammatory response. These findings were verified by real time PCR and in some cases at the protein level by immunoblotting or immunohistochemistry.

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METTL3 mediates m6A modification of hsa_circ_0072380 to regulate the progression of gestational diabetes mellitus

Project description:M6A modification plays a vital role in gestational diabetes mellitus (GDM) progression. However, the role of METTL3 and differential m6A-modified circRNAs in GDM stay to be investigated. Placental tissue samples from GDM patients and normal controls (NC) were collected to measure changes in m6A modification levels. MeRIP-seq on placental tissue was performed to detect differential m6A-modified circRNAs.High glucose (HG)-treated JEG3 cells were used to establish the GDM cell model. Differentially expressed circRNAs levels in GDM and NC groups was measured by qRT-PCR. We knocked down METTL3 to study its function. Additionally, we conducted functional recovery experiments. Dot blot assay was utilized to assess changes in m6A levels. MeRIP-qPCR was performed to evaluate the effect of knocking down METTL3 on m6A modification of hsa_circ_0072380 in JEG3 cells. Compared with NC group, GDM group exhibited increased levels of m6A modification and METTL3 expression. Differences in m6A modification of circRNAs exist between the GDM and NC groups. Hsa_circ_0000994, hsa_circ_0058733, and hsa_circ_0072380 were significantly down-regulated in GDM group while hsa_circ_0036376, hsa_circ_0000471, and hsa_circ_0001173 showed no significant differences between two groups. HG treatment promoted METTL3 expression and m6A level of JEG3 cells, and inhibited cell proliferation, migration, and invasion abilities. Knocking down METTL3 reversed these effects. After HG treatment, hsa_circ_0072380 was significantly down-regulated. Knocking down METTL3 led to up-regulation of hsa_circ_0072380, while knocking down hsa_circ_0072380 restored the function of SiMETTL3. Additionally, knocking down METTL3 significantly reduced m6A modification of hsa_circ_0072380. METTL3 mediated m6A modification of hsa_circ_0072380 to regulate GDM progression.

2024-12-16 | GSE250374 | GEO

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