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Transcriptome profiling of mouse CD8+ T cells in the presence or absence of acetate

ABSTRACT: Transcriptome profiling of mouse CD8+ T cells in the presence or absence of acetate

PROVIDER: PRJNA898970 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22213556_1.fastq.gz	Fastqsanger.gz
	SRR22213556_2.fastq.gz	Fastqsanger.gz
	SRR22213557_1.fastq.gz	Fastqsanger.gz
	SRR22213557_2.fastq.gz	Fastqsanger.gz
	SRR22213558_1.fastq.gz	Fastqsanger.gz

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Transcriptome profiling of mouse CD8+ T cells in the presence or absence of acetate

Project description:To investigate the role of acetate in T cell survival and the underlying mechanism, transcription profiling was performed on mouse CD8+ T cells treated with or without 10mM acetate for 24h. We then performed gene expression profiling analysis using data obtained from RNA-seq of mouse CD8+ T cells.

2023-06-22 | GSE217411 | GEO

Transcriptome profiling of control cells or the A549 cells in the presence or absence of acetate following TGF-β1 stimulation

Project description:Purpose: To compare the transcriptome profiling of control cells or the A549 cells in the presence or absence of acetate following TGF-β1 stimulation. Methods: A549 cells were treated with control, TGF-β1 or TGF-β1 plus acetate for 2 days. And then, we performed RNA sequencing for transcription profiling of control cells or the A549 cells in the presence or absence of acetate following TGF-β1 stimulation. The raw data were processed with bcl2fastq software and HISAT2. Results: From the transcriptome profiling and analysis, we got gene expression data of control group and in the presence or absence of acetate following TGF-β1 stimulation using A549 cells. Conclusion: The gene expression data revealed the transcriptome variation by TGF-β1 treatment and acetate can reverse TGF-β1 effect.

2022-06-14 | GSE197132 | GEO

Transcriptome profiling of mouse CD4+ T cells in the presence or absence of acetate

Project description:Transcriptome profiling of mouse CD4+ T cells in the presence or absence of acetate

| PRJNA939239 | ENA

Next-generation RNA sequencing of Acetate treated primary cultured mouse astrocytes in the presence or absence of Aβ

Project description:Reactive astrogliosis is a well-known and recognised marker of Alzheimer's Disease (AD). The aim of this study is to functionally visualise reactive astrocyte-mediated neuronal hypometabolism in the brains that is associated with AD and neuroinflammation. To investigate alterations of acetate and glucose metabolism and the effect thereof in AD-like astrocytes, primary astrocyte cultures were treated with acetate in the presence or absence of amyloid beta (Aβ) oligomers. On comparison, we found that acetate treatment upregulated the expression of acetate transporter MCT1 (Slc16a1) as well as that of enzymes involved in the urea cycle and subsequent GABA synthesis. We could, therefore, conclude that MCT1-mediated uptake of acetate into astrocytes triggered GABA synthesis by upregulating enzymes involved in putrescine production and degradation.

2023-04-03 | GSE228468 | GEO

Transcriptome profiling of mouse CD4+ T cells in the presence or absence of acetate

Project description:Transcription profiling was performed on mouse CD4+ T cells treated with or without 10 mM acetate for 24 h. We then performed gene expression profiling analysis using data obtained from RNA-seq of mouse CD4+ T cells.

2023-06-22 | GSE226252 | GEO

Expression data from naive and memory CD8 T cells cultured in presence or absence of IL-4

Project description:Effects of IL-4 on CD8 T cells functions are largely unknown. IL-4 induces survival and proliferation of CD8 T cells, but several studies suggest that IL-4 could also affect several functions of CD8 T cells such as cytotoxicity. Our team has shown that IL-4 repress the expression of Ccl5 in vitro. To define more precisely the impact of IL-4 on CD8 T cells, we performed a whole genome expression microarray analysis of naive and memory CD8 T cells cultured in presence or absence of IL-4. This approach allowed us to define the IL4-gene-expression signature on CD8 T cells. 18 samples were processed. Two populations of F5 naive CD8 T cells were FACS-sorted: samples from each population were incubated 20 hours with IL-7 in presence or absence of IL-4. Thus, a total of 6 “Naive” samples were processed. In addition, 4 populations of F5 TIM memory CD8 T cells were FACS-sorted: samples from 2 of these populations were incubated 20 hours in presence of IL-7 and/or IL-4, or in medium alone. Thus, 12 “Memory” samples were processed.

2011-09-27 | E-GEOD-32423 | biostudies-arrayexpress

Transcriptome profiling of control cells or the A549 cells in the presence or absence of acetate following TGF-β1 stimulation

Project description:Transcriptome profiling of control cells or the A549 cells in the presence or absence of acetate following TGF-β1 stimulation

| PRJNA809029 | ENA

Expression data from naive and memory CD8 T cells cultured in presence or absence of IL-4

2011-09-28 | GSE32423 | GEO

Next-generation RNA sequencing of Acetate treated primary cultured mouse astrocytes in the presence or absence of Aβ

Project description:Next-generation RNA sequencing of Acetate treated primary cultured mouse astrocytes in the presence or absence of Aβ

| PRJNA949988 | ENA

Memory CD8+ T cells require stress-levels of acetate for optimal function

Project description:How systemic metabolic alterations during acute infections impact immune-cell function remains poorly understood. Hess and colleagues demonstrate that acetate rapidly increases during infections, which drives acetylation of GAPDH in memory CD8+ T cells and thereby catalyzes the rapid recall response. Comparison of mRNA profile of control vs. 3d acetate exposed memory OT-I T cells

2016-05-18 | E-GEOD-79600 | biostudies-arrayexpress

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