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Small molecular ALA targets ELK1 to balance human neutrophil and erythroid differentiation

ABSTRACT: Small molecular ALA targets ELK1 to balance human neutrophil and erythroid differentiation

PROVIDER: PRJNA901182 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22270501_1.fastq.gz	Fastqsanger.gz
	SRR22270501_2.fastq.gz	Fastqsanger.gz
	SRR22270502_1.fastq.gz	Fastqsanger.gz
	SRR22270502_2.fastq.gz	Fastqsanger.gz
	SRR22270503_1.fastq.gz	Fastqsanger.gz

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Small molecular ALA targets ELK1 to balance human neutrophil and erythroid differentiation

Project description:Alpha lipoic acid is reported to inhibit neutrophil lineage determination by targeting transcription factor ELK1 in granulocyte-monocyte progenitors. Here, we provide new evidence of alpha lipoic acid in promoting erythroid differentiation by targeting transcription factor ELK1 in CD34+CD371– hematopoietic stem progenitor cells. Over expression of both L-ELK1 and S-ELK1 greatly inhibit erythroid cell differentiation, but not knocking down of ELK1. Thus, RNAseq of CD34+CD123+CD38+CD371– HSPCs is performed to dissect the molecular mechanism of ELK1 in blocking erythrocyte differentiation.

2023-06-01 | GSE217887 | GEO

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