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Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice [scRNA-seq]

ABSTRACT: Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice [scRNA-seq]

PROVIDER: PRJNA903193 | ENA |

REPOSITORIES: ENA

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Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice [scRNA-seq]

Project description:Peripheral inflammation has been associated with various neurodegeneration, including Alzheimer's Disease (AD). In this study, we employed an AD mouse model nasally infected with Staphylococcus aureus to assess the impact of chronic or acute peripheral inflammation on brain transcriptome and amyloid pathology. The chronic exposure increased the diffuse and compact amyloid plaques and blood cytokine levels. Following a short-term exposure, single-cell and spatial transcriptomics uncovered cell type- and spatial-specific transcriptional changes indicating a dysregulation of the brain barriers, including the blood-brain and the blood-cerebrospinal fluid barriers. Brain macrophages exhibited increased Apoe expression and macrophage-specific genes were upregulated at ventricular areas of infected mice. In addition, we report an increase of disease associated microglia genes around the A plaques, together with disbalances in neuronal expression in response to peripheral inflammation. Overall, results enlighten the mechanisms linking peripheral inflammation to AD.

2023-07-15 | GSE218352 | GEO

Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice [spatial transcriptomics]

2023-07-15 | GSE218360 | GEO

Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice

Project description:Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice

| PRJNA903210 | ENA

Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice [spatial transcriptomics]

Project description:Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice [spatial transcriptomics]

| PRJNA903211 | ENA

Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice [RNA-seq]

2023-07-15 | GSE218346 | GEO

Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice [RNA-seq]

Project description:Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice [RNA-seq]

| PRJNA903187 | ENA

Identification of aberrant circRNAs in peripheral whole blood of patients with Alzheimer's disease

Project description:We try to identify the aberrant circRNAs in peripheral whole blood of patients with Alzheimer's disease by circular RNA microarray.

2020-12-15 | GSE161435 | GEO

Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-07-15 | GSE218361 | GEO

Single-cell transcriptomics implicate the alteration of peripheral immune cells and interaction with renal macrophages driven by T2DM

Project description:The alternation of peripheral immune cells in diabetes is complicated. We performed scRNA-seq on db/db mice to explore the cellular changes in T2DM.

2023-12-01 | GSE216886 | GEO

Human Microglial State Dynamics in Alzheimer's Disease Progression [scRNA-seq]

Project description:Human Microglial State Dynamics in Alzheimer's Disease Progression [scRNA-seq]

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