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Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice

ABSTRACT: Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice

PROVIDER: PRJNA903210 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22337703_1.fastq.gz	Fastqsanger.gz
	SRR22337703_2.fastq.gz	Fastqsanger.gz
	SRR22337705_1.fastq.gz	Fastqsanger.gz
	SRR22337705_2.fastq.gz	Fastqsanger.gz
	SRR22337707_1.fastq.gz	Fastqsanger.gz

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Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice [spatial transcriptomics]

Project description:Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice [spatial transcriptomics]

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Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice [scRNA-seq]

Project description:Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice [scRNA-seq]

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Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice [spatial transcriptomics]

Project description:Peripheral inflammation has been associated with various neurodegeneration, including Alzheimer's Disease (AD). In this study, we employed an AD mouse model nasally infected with Staphylococcus aureus to assess the impact of chronic or acute peripheral inflammation on brain transcriptome and amyloid pathology. The chronic exposure increased the diffuse and compact amyloid plaques and blood cytokine levels. Following a short-term exposure, single-cell and spatial transcriptomics uncovered cell type- and spatial-specific transcriptional changes indicating a dysregulation of the brain barriers, including the blood-brain and the blood-cerebrospinal fluid barriers. Brain macrophages exhibited increased Apoe expression and macrophage-specific genes were upregulated at ventricular areas of infected mice. In addition, we report an increase of disease associated microglia genes around the A plaques, together with disbalances in neuronal expression in response to peripheral inflammation. Overall, results enlighten the mechanisms linking peripheral inflammation to AD.

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Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice [scRNA-seq]

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Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice [RNA-seq]

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Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice.

Project description:Peripheral inflammation has been linked to various neurodegenerative disorders, including Alzheimer's disease (AD). Here we perform bulk, single-cell, and spatial transcriptomics in APP/PS1 mice intranasally exposed to Staphylococcus aureus to determine how low-grade peripheral infection affects brain transcriptomics and AD-like pathology. Chronic exposure led to increased amyloid plaque burden and plaque-associated microglia, significantly affecting the transcription of brain barrier-associated cells, which resulted in barrier leakage. We reveal cell-type- and spatial-specific transcriptional changes related to brain barrier function and neuroinflammation during the acute infection. Both acute and chronic exposure led to brain macrophage-associated responses and detrimental effects in neuronal transcriptomics. Finally, we identify unique transcriptional responses at the amyloid plaque niches following acute infection characterized by higher disease-associated microglia gene expression and a larger effect on astrocytic or macrophage-associated genes, which could facilitate amyloid and related pathologies. Our findings provide important insights into the mechanisms linking peripheral inflammation to AD pathology.

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Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-07-15 | GSE218361 | GEO

Identification of aberrant circRNAs in peripheral whole blood of patients with Alzheimer's disease

Project description:We try to identify the aberrant circRNAs in peripheral whole blood of patients with Alzheimer's disease by circular RNA microarray.

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