Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene regulatory basis of bystander activation in CD8+ T cells (scRNA-seq)

ABSTRACT: Gene regulatory basis of bystander activation in CD8+ T cells (scRNA-seq)

PROVIDER: PRJNA903887 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22358113.fastq.gz	Fastqsanger.gz
	SRR22358114.fastq.gz	Fastqsanger.gz
	SRR22358115.fastq.gz	Fastqsanger.gz
	SRR22358116.fastq.gz	Fastqsanger.gz
	SRR22358117.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 32

Similar Datasets

Gene regulatory basis of bystander activation in CD8+ T cells (human scRNA-seq)

Project description:Gene regulatory basis of bystander activation in CD8+ T cells (human scRNA-seq)

| PRJNA1085376 | ENA

Gene regulatory basis of bystander activation in CD8+ T cells

Project description:Gene regulatory basis of bystander activation in CD8+ T cells

| PRJNA749290 | ENA

Gene regulatory basis of bystander activation in CD8+ T cells (scATAC-seq)

Project description:Gene regulatory basis of bystander activation in CD8+ T cells (scATAC-seq)

| PRJNA902762 | ENA

Gene regulatory basis of bystander activation in CD8+ T cells (ATAC-seq)

Project description:Gene regulatory basis of bystander activation in CD8+ T cells (ATAC-seq)

| PRJNA749294 | ENA

Gene regulatory basis of bystander activation in CD8+ T cells (RNA-seq)

Project description:Gene regulatory basis of bystander activation in CD8+ T cells (RNA-seq)

| PRJNA749293 | ENA

Gene regulatory basis of bystander activation in CD8+ T cells (scRNA-seq)

Project description:CD8+ T cells have been categorized as an adaptive lymphocyte, based on their ability to recognize specific foreign antigens and mount memory responses. However, neonatal and adult CD8+ T cells are derived from distinct HSC progenitors, which may alter the roles they play during infection. Here, we demonstrate that neonatal CD8+ T cells can be activated by innate cytokines alone and protect the host from a variety of unrelated pathogens in the absence of TCR signaling. Using a multi-omics approach, we found that neonatal CD8+ T cells are highly responsive to innate cytokines because they can rapidly undergo chromatin remodeling, resulting in the usage of a distinct set of enhancers that are more commonly found in innate-like T cells. We also identified a key gene regulatory axis (Bach2/AP1) that is differentially utilized by neonatal and adult CD8+ T cells to toggle their responsiveness to innate cytokines. Importantly, the developmental switch between innate and adaptive functions in the CD8+ T cell compartment is not mediated by a change in the maturation of individual cells along a linear axis, but rather by changes in the abundance of distinct subsets of cells. Collectively, our findings provide support for the layered immune hypothesis and indicate that the CD8+ T cell compartment is more phenotypically diverse than previously thought.

2024-02-26 | GSE218456 | GEO

After virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism

Project description:CD8 T cells play a central role in antiviral immunity. Type I interferons are among the earliest responders after virus exposure and can cause extensive reprogramming and antigen-independent bystander activation of CD8 T cells. Although bystander activation of pre-existing memory CD8 T cells is known to play an important role in host defense and immunopathology, its impact on naïve CD8 T cells remains underappreciated. Here we report that exposure to reovirus, both in vitro or in vivo, promotes bystander activation of naïve CD8 T cells within 24 hours and that this distinct subtype of CD8 T cell displays an innate, antiviral, type I interferon sensitized signature. The induction of bystander naïve CD8 T cells is STAT1 dependent and regulated through nicotinamide phosphoribosyl transferase (NAMPT)-mediated enzymatic actions within NAD+ salvage metabolic biosynthesis. These findings identify a novel aspect of CD8 T cell activation following virus infection with implications for human health and physiology.

2023-01-30 | PXD039614 | Pride

Gene regulatory basis of bystander activation in CD8+ T cells (human scRNA-seq)

2024-03-11 | GSE261140 | GEO

Gene regulatory basis of bystander activation in CD8+ T cells (scATAC-seq)

2024-02-26 | GSE218223 | GEO

Gene regulatory basis of bystander activation in CD8+ T cells (ATAC-seq)

Project description:The immune system is stratified into layers of specialized cells with distinct functions. Recently, Lin28b was shown to serve as a master regulator of fetal lymphopoiesis and program the development of more innate-like lymphocytes in early life. However, it is still unclear how Lin28b alters the function of fetal-derived lymphocytes and protects the host against infection. In this report, we examined how Lin28b transcriptionally and epigenetically programs murine CD8+ T cells for innate immune defense and translated our key findings to human CD8+ T cells. We found that Lin28b operates as a gatekeeper, opening the door to a hidden diversity of phenotypes that are unveiled upon stimulation with innate cytokines. In particular, Lin28b promotes a transcriptionally and functionally diverse pool of cells through chromatin remodeling. As a result, neonatal CD8+ T cells are able to deploy a bet-hedging immune strategy and protect the host against a wide range of unrelated pathogens.

2024-02-26 | GSE180731 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data