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Transcriptional Profiling of the Metanephric Kidney

ABSTRACT: Transcriptional Profiling of the Metanephric Kidney

PROVIDER: PRJNA90417 | ENA |

REPOSITORIES: ENA

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Transcriptional Profiling of the Metanephric Kidney

Project description:In this study we identify molecules with highly restricted expression patterns during the initial stages of metanephric development, when the ureteric bud has entered the metanephric mesenchyme and initiated branching morphogenesis. Using the Affymetrix Mouse Genome 430 2.0 Array, we compare gene expression patterns in ureteric bud tips, stalks and metanephric mesenchymes from mouse E12.5 embryos. To identify conserved molecular pathways, we also analyze transcriptional profiles in rat E13.5 ureteric buds and metanephric mesenchymes using the Affymetrix Rat Genome U34 Set. Taken together, these data sets help to identify conserved and highly localized transcripts in the metanephric kidney. Keywords = Mus musculus Keywords = Rattus norvegicus Keywords = metanephric mesenchyme Keywords = ureteric bud Keywords = ureteric bud tips Keywords = ureteric bud stalks Keywords = molecular screen for spatially restricted transcripts Keywords: other

2005-07-01 | GSE1983 | GEO

Complete embryonic E11.5 metanephric kidney analysis of wild type and Hoxa11, Hoxd11 null targeted mice

2006-05-01 | GSE3822 | GEO

Transcriptional profile of E14.5 micro-dissected kidney structures: renal vesicle, s-shaped body & collecting duct (MG_U74Av2 platform). (GUDMAP Series ID: 9)

Project description:Our laboratory's interest is in understanding the molecular principles that underlie the regional organization of the mammalian metanephric kidney. Our goal is to generate a detailed spatial map of the cellular expression of selected regulatory genes during mammalian kidney development. The goal of this study is to identify genes expressed during the morphogenesis of the nephron. By profiling two specific developmental nephron structures, we expect to identify genes expressed in both, and unique to each, which suggests they may play a role in the underlying mechanism responsible for the morphogenesis. Keywords: kidney component comparison

2006-11-18 | GSE6309 | GEO

Transcriptional profile of E14.5 micro-dissected kidney structures: renal vesicle, s-shaped body & collecting duct (MOE430A platform). (GUDMAP Series ID: 8)

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Single-nucleus transcriptional profiling of chronic kidney disease after cisplatin nephrotoxicity

Project description:Single-nucleus transcriptional profiling of chronic kidney disease after cisplatin nephrotoxicity

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Transcription profiling of initial stages of metanephric development in mouse and rat

2007-07-24 | E-GEOD-1983 | biostudies-arrayexpress

Transcriptional profiling

Project description:Transcriptional profiling

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Expression data from embryonic rat kidney timepoints and a budded WD-MM recombination tissue

Project description:Here we compared the expression of an engineered kidney tissue, created by recombining an in vitro budded Wolffian duct with fresh E13 metanephric mesenchyme, with that of three in vivo rat embryonic kidney timepoints (E13, E18, and week 4) Keywords: time course

2007-11-30 | GSE9570 | GEO

The developmental programme for genesis of the entire kidney is recapitulated in Wilms tumour

Project description:Expression profiling of Wilms tumour samples, which identified molecular signatures of the ureteric bud and collecting duct as well as those of the proximal and distal tubules in triphasic histology tumours. These observations indicate Wilms tumours can arise from a precursor cell capable of generating the entire kidney, such as the cells of the intermediate mesoderm from which both the metanephric mesenchym and ureteric bud are derived.

2017-12-31 | E-MTAB-3516 | biostudies-arrayexpress

Transcription profiling of wild type and HoxA11 metenephric mesenchyme and ureteric bud from embryonic day 11.5 mice

Project description:E11.5 metanephric mesenchyme and ureteric bud were dissected from the E11.5 kidney rudiment using fine manual microdissection (ureteric bud only) or both fine manual microdissection and laser capture microdissection (metanephric mesenchyme) to define the gene expression profiles of these structures. Additionally, HoxA11, HoxD11 compound null E11.5 metanephric mesenchyme was obtained through laser capture microdissection allowing analysis of possible Hox targets in kidney development. Targets from multiple biological replicates of each were generated and the expression profiles were determined using Affymetrix MOE430_v2 arrays. Using microdissection techniques, ureteric bud and metanephric mesenchyme were dissected from E11.5 kidney rudiments allowing the identificated genes specifically regulated in either structure. In addition, Hoxa11, Hoxd11 compound null E11.5 metanephric mesenchyme were normalized to wild type embryonic controls allowing the identification of potential Hox targets in normal kidney development. Each structure/genotype were represented in biological (seperate embryo) replicate.

2007-12-07 | E-GEOD-3822 | biostudies-arrayexpress

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