Project description:To investigate the function of A3B, we established 92.1 cell lines with A3B knocked down and MEL290 cell lines with A3B overexpression. We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 different cell lines with two replicates.

2023-06-07 | GSE218751 | GEO

Decoding the Epigenetics and Chromatin Loop Dynamics of Androgen Receptor-Mediated Transcription

Project description:Decoding the Epigenetics and Chromatin Loop Dynamics of Androgen Receptor-Mediated Transcription

| PRJNA1055889 | ENA

Effect of overexpression of A3B and RNA editing calling in mouse tissues [WES]

Project description:To test if A3B has RNA editing activity we performed SNV calling from WES of 8 mouse livers (Samples 1-8) and 8 pancreas (Samples 7-16)

2023-07-25 | GSE209722 | GEO

Decoding the Epigenetics and Chromatin Loop Dynamics of Androgen Receptor-Mediated Transcription [HiChIP]

Project description:Decoding the Epigenetics and Chromatin Loop Dynamics of Androgen Receptor-Mediated Transcription [HiChIP]

| PRJNA1055896 | ENA

Genome-wide Map of R-loop Reveals its interplays with Transcription and Genome Integrity during Germ Cell Meiosis

Project description:R-loop is a three-strand nucleic acid structure composed of mRNA and DNA. In mammalian meiotic cells, R-loop mainly distributed at promoter-related regions, and combined with systematically transcriptome analysis showed R-loop was closely related to transcription in meiotic process. Moreover, knockout of Rnaseh1 in meiotic cells caused mice completely sterile with R-loop accumulation and abnormal DSB repairing in spermatocytes. Further analysis showed R-loop accumulation in leptotene/zygotene influenced transcriptional regulation in pachytene stage. Thus, mutual regulation of R-loop and transcription plays essential role in spermatogenesis.

2023-09-21 | GSE190430 | GEO

Decoding the Epigenetics and Chromatin Loop Dynamics of Androgen Receptor-Mediated Transcription [ATAC-seq]

Project description:Decoding the Epigenetics and Chromatin Loop Dynamics of Androgen Receptor-Mediated Transcription [ATAC-seq]

| PRJNA1055893 | ENA

Decoding the Epigenetics and Chromatin Loop Dynamics of Androgen Receptor-Mediated Transcription [ChIP-seq]

Project description:Decoding the Epigenetics and Chromatin Loop Dynamics of Androgen Receptor-Mediated Transcription [ChIP-seq]

| PRJNA1055894 | ENA