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Aiolos modulates IL-15 responsiveness of intestinal intraepithelial lymphocytes [CUT&RUN]

ABSTRACT: Aiolos modulates IL-15 responsiveness of intestinal intraepithelial lymphocytes [CUT&RUN]

PROVIDER: PRJNA908089 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22515738_1.fastq.gz	Fastqsanger.gz
	SRR22515738_2.fastq.gz	Fastqsanger.gz
	SRR22515739_1.fastq.gz	Fastqsanger.gz
	SRR22515739_2.fastq.gz	Fastqsanger.gz
	SRR22515740_1.fastq.gz	Fastqsanger.gz

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Aiolos modulates IL-15 responsiveness of intestinal intraepithelial lymphocytes [CUT&RUN]

Project description:Intestinal intraepithelial lymphocytes (IEL) are capable of rapid innate-like responses to microenvironmental cues. While poised to activation, IEL effector functions must be stringently controlled. Aiolos is an Ikaros zinc finger (IKZF) family member encoded by Ikzf3 that promotes histone deacetylation. Here, we found that Aiolos is a crucial regulator of IEL activation. Ikzf3–/– CD8αα+ IEL expressed high levels of innate NK receptors, cytotoxic enzymes, cytokines and chemokines. Single cell RNAseq of IEL revealed that Ikzf3 deficiency mostly amplified the effector machinery of a CD8αα+ IEL subset characterized by high expression CD122, the receptor for IL-15. Furthermore, Ikzf3 deficiency increased IEL responsiveness to IL-15. Aiolos binding sites were close to those for STAT5 and RUNX transcription factors that promote IL-15 signaling and cytolytic programs, respectively; lack of Ikzf3 increased accessibility and histone acetylation of these chromatin regions. Ikzf3 deficiency increased susceptibility to colitis, demonstrating the functional relevance of Aiolos-mediated regulation of IEL effector functions.

2023-10-20 | GSE220022 | GEO

Aiolos modulates IL-15 responsiveness of intestinal intraepithelial lymphocytes

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Aiolos modulates IL-15 responsiveness of intestinal intraepithelial lymphocytes [scRNA-seq]

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Aiolos modulates IL-15 responsiveness of intestinal intraepithelial lymphocytes [ATAC-seq]

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Aiolos modulates IL-15 responsiveness of intestinal intraepithelial lymphocytes [RNA-seq]

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Aiolos modulates IL-15 responsiveness of intestinal intraepithelial lymphocytes [ATAC-seq]

Project description:Aiolos modulates IL-15 responsiveness of intestinal intraepithelial lymphocytes [ATAC-seq]

| PRJNA908082 | ENA

Aiolos modulates IL-15 responsiveness of intestinal intraepithelial lymphocytes [RNA-seq]

Project description:Aiolos modulates IL-15 responsiveness of intestinal intraepithelial lymphocytes [RNA-seq]

| PRJNA908083 | ENA

Aiolos modulates IL-15 responsiveness of intestinal intraepithelial lymphocytes [scRNA-seq]

Project description:Aiolos modulates IL-15 responsiveness of intestinal intraepithelial lymphocytes [scRNA-seq]

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Aiolos modulates IL-15 responsiveness of intestinal intraepithelial lymphocytes

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-10-20 | GSE220030 | GEO

Comparison of gamma delta intraepithelial lymphocytes from DSS-treated and untreated colon

Project description:gamma delta intraepithelial lymphocytes were isolated from the colons of DSS-treated and untreated mice. Total RNAs were isolated and compared by Affymetrix DNA microarray. Duplicate comparisons were made between DSS-treated and untreated gamma delta intraepithelial lymphocytes.

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