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Effects of gene expression changes by Ephexin1 deficiency in HCT116 cells

ABSTRACT: Effects of gene expression changes by Ephexin1 deficiency in HCT116 cells

PROVIDER: PRJNA910946 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22677373_1.fastq.gz	Fastqsanger.gz
	SRR22677373_2.fastq.gz	Fastqsanger.gz
	SRR22677374_1.fastq.gz	Fastqsanger.gz
	SRR22677374_2.fastq.gz	Fastqsanger.gz
	SRR22677375_1.fastq.gz	Fastqsanger.gz

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Effects of gene expression changes by Ephexin1 deficiency in HCT116 cells

Project description:To investigate Ephexin1-induced gene changes in colon cells, we established HCT116 cell line knocked down by Ephexin1-shRNA. We then performed gene expression profiling analysis using the data obtained from RNA-seq of shControl and shEphexin1.

2025-01-31 | GSE220669 | GEO

Effects on gene expression by Aff3-deficiency

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Effects of DAB2IP depletion on gene expression in HCT116 cells

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Gene expression changes in human colorectal cell line HCT116 DICER Exon5 knockout cells

Project description:The experiment was to study the gene expression changes in human colorectal cell HCT116 DICER Exon5 knockout cells comparing to that in parental HCT116 cellls. Keywords: Cell type comparison

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Transcriptomic changes in HCT116 cells after KAT2A knockout

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Comparison of effects of Iodine-deficiency and perchlorate on thyroid

Project description:Perchlorate, which is a ubiquitous and persistent ion, competitively interferes with iodide accumulation in the thyroid, causing iodine deficiency, which may result in reduced thyroid hormone synthesis and secretion. Human studies suggest that perchlorate presents very little risk in healthy individuals; however, the precautionary principle demands that the sensitive populations of iodine deficient adults and mothers require extra consideration. In an attempt to determine if the effects on gene expression were similar, we compared the thyroidal effects of perchlorate (10 mg/kg) treatment for 14 days in drinking water with those caused by 8 weeks of Iodine-deficiency in rats. The thyroids were collected (N=3 each group) and total mRNA was analyzed using the Affymetrix Rat Genome 230 2.0 GeneChip®. Changes in gene expression were compared with appropriate control groups. We compared the 2-fold gene changes due to I-deficiency with changes due to perchlorate treatment. 189 transcripts were changed by the Iodine-deficient diet and 722 transcripts were changed by the perchlorate treatment. 34% of the transcripts changed by the I-deficient diet were also changed by perchlorate and generally in the same direction. three specific transporter genes, AQP1, NIS, & SLC22A3 were changed by both treatments, indicating that the membrane specific changes were similar. Iodine-deficiency primarily caused changes in retinol and calcium signaling pathways and perchlorate primarily caused changes related to the accumulation of extracellular matrix proteins. This study provides evidence that perchlorate, at least at this dose level, changes more genes and changes different genes compared to iodine deficiency. Changes in gene expression due to I-deficiency compared to normal diet for 2 months. Changes in gene expression due to perchlorate in the drinking water compared to normal drinking water for 1 or 14 days. Feeding study in rats.

2010-11-04 | E-GEOD-25144 | biostudies-arrayexpress

Effects of DAB2IP depletion on gene expression in HCT116 cells

Project description:To study DAB2IP function on colon cancer, we depleted DAB2IP in HCT116 cells using shDAB2IP or shCNT(scramble) as a control.

2023-03-05 | GSE224870 | GEO

Transcriptional changes associated with miR-6762-5p expression in HCT116 cells

Project description:Transcriptional changes associated with miR-6762-5p expression in HCT116 cells

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Effects of Mysm1 deficiency on gene expression across a range of mouse tissues and cell types

Project description:This SuperSeries is composed of the following subset Series: GSE34282: Effects of Mysm1 deficiency on gene expression across a range of mouse tissues and cell types (tissue data) GSE34284: Effects of Mysm1 deficiency on gene expression across a range of mouse tissues and cell types (cell data) Refer to individual Series

2012-01-01 | E-GEOD-34285 | biostudies-arrayexpress

Gene expression underlying the effects of biotin deficiency in rat liver, worms and yeast

Project description:Biotin is cofactor of crucial enzymes for intermediary metabolism, and its deficiency affects the transcription of some critical genes of mammalian glucose metabolism. However, the precise mechanisms of biotin starvation on gene expression are unknown. Here we show that metabolic changes ushered by deficiency of this vitamin sets in motion extensive reorganization of carbon metabolism gene expression, consistent across three diverse eukaryotes, that is mediated through a regulatory circuitry at the genome level similar in the three species. We used affymetrix microarrays to detail the global gene expression underlying the effects of biotin deficiency in Rattus norvegicus liver, Caenorhabditis elegans and Saccharomyces cerevisiae and identified distinct classes of up-regulated genes during this event.

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