VIR-M-SHR-2
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA911055 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Vir/pvpir genes, a multigene family in Plasmodium vivax that are a part of a larger superfamily of genes called the pir (Plasmodium interspersed repeat) genes have been reported earlier to be possibly involved in cytoadherence and evasion of splenic clearance. Plasmodium vivax, historically characterized as a "benign" malaria parasite, has been associated with clinical outcomes including hepatic dysfunction, renal failure, and cerebral malaria in India and several global regions. It constitutes an economic burden and presents a public health challenge alongside other Plasmodium species. Here, we present a part of global transcriptomic studies by custom designed microarray, that compare the transcriptome of the parasite responsible for severe Plasmodium vivax manifestations, specifically hepatic dysfunction and cerebral malaria from India, with an emphasis on the vir/pvpir genes, some of which are reported to play a role in cytoadherence. 23 patients with Plasmodium vivax malaria (Uncomplicated=6, Hepatic dysfunction=12 and Cerebral malaria=5) were subjected to microarray hybridization and the data so obtained showed a wide range of vir/pvpir subtelomeric subfamilies have been differentially expressed. Upregulation has been seen in 24 vir/pvpir genes in cerebral malaria samples (n=5) and 28 genes in hepatic dysfunction samples (n=12) belonging to different subfamily in at least 50% of the patient samples. Out of the upregulated vir/pvpir genes in cerebral malaria manifestation, members of vir subfamily E and pvpir H are maximum in number whereas in hepatic dysfunction manifestation, members of vir subfamily E and C comprise a significant proportion.
2026-02-12 | GSE301003 | GEO
Project description:Transcriptional profiling in the shoot after SHR induction by DEX. We used Affymetrix ATH1 microarrays to identify new target genes of SHR and the effect of SHR on growth and development of the Arabidopsis shoot system by global transcriptome analysis.
2014-11-12 | GSE63207 | GEO
Project description:The goals of this study is to compare the differently expressed genes in abdominal aorta tissue of WKY and SHR as well as differently expressed genes in the abdominal aorta tissue of SHR with or without neferine treatment. The rat (n=15) were randomly divided into 3 groups: WKY,SHR, and SHR + neferine - H (high concentration) groups (n=6 for each group). Rat in WKY and SHR groups were intragastrically with double distilled water (dd H2O); while rat in SHR + SHR + neferine - H groups were intragastrically with 10mg/kg/D of neferine for 10 weeks. Then the abdominal aorta were used to identify differentially expressed genes among different groups.
2022-10-06 | GSE214655 | GEO
Project description:SHR is a key regulator of stem cell renewal and radial patterning in the Arabidopsis root. In previous studies we showed that the SHR is a transcriptional regulator and it regulates gene transcription directly. To fully understand the SHR developmental pathway, we aim to identify its direct target at the genome scale using the ChIP-on-chip method. To this end, we have designed a promoter microarray for Arabidopsis, which contains probes that tile the intergenic regions as well as the first intron and the 3' UTR for all annotated genes including miRNA genes. Chromatin immunoprecipitation (ChIP) was performed using an anti-GFP antibody on the root of a transgenic line expressing under the SHR promoter a functional fusion protein between SHR and GFP. After labeling with Cy5 and Cy3 respectively, DNA recoverd from the ChIP and mock experiments was hybridized to the same microarray. The array was scanned using an Agilent scanner and the signal intensity for each channel was retrieved and normalized by the Agilent feature extraction software.
2010-07-19 | GSE21338 | GEO
Project description:Transcriptional profiling of the vegetative part of Arabidopsis comparing wild type with the shr scl23 scr triple mutant. The latter is produced by crossing the strong null alleles of shr (shr-2), scl23 (scl23-1) and scr (scr-5). The goal was to determine the effects of the GRAS transcription factors SHR, SCL23 and SCR on growth and development of the Arabidopsis shoot system by global transcriptome analysis.
2012-10-11 | GSE41478 | GEO
Project description:We used Nimblegen HD aCGH to detect copy-number variants between genomes of BN and SHR rats
2010-01-30 | GSE20102 | GEO
Project description:Alterations in DNA methylation between WKY and SHR epithelium
2019-05-04 | GSE130669 | GEO
Project description:Alterations in genes between WKY and SHR epithelium
2019-05-04 | GSE130658 | GEO
Project description:Asymmetric division of cortex/endodermal initials (CEI) in the Arabidopsis root generates two layers of ground tissue and is controlled by a finely orchestrated interplay between the transcription factors, SHORT ROOT (SHR) and SCARECROW (SCR). To understand the dynamics of the SHR/SCR regulatory network we performed microarray time course experiments using inducible versions of SHR and SCR and examined their transcriptional effects specifically in the ground tissue. Keywords: SHR and SCR time course and CEI cell-type analyses
2010-07-19 | GSE15876 | GEO
Project description:Rattus norvegicus strain:SHR Transcriptome or Gene expression
| PRJNA226588 | ENA