Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Bre1-mediated Set2 protein degradation promotes chronological aging in budding yeast [ChIP-seq]

ABSTRACT: Bre1-mediated Set2 protein degradation promotes chronological aging in budding yeast [ChIP-seq]

PROVIDER: PRJNA912607 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22746561_1.fastq.gz	Fastqsanger.gz
	SRR22746561_2.fastq.gz	Fastqsanger.gz
	SRR22746562_1.fastq.gz	Fastqsanger.gz
	SRR22746562_2.fastq.gz	Fastqsanger.gz
	SRR22746563_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 32

Similar Datasets

Bre1-mediated Set2 protein degradation promotes chronological aging in budding yeast [ChIP-seq]

Project description:Histone modification affects life span in various organisms. The loss of Histone H3K36 methylation can shorten replicative life span in Saccharomyces cerevisiae. However, budding yeast, as a model organism for aging research, has replicative life span (RLS) and chronological life span (CLS). In this study, we showed that the loss of Histone H3K36 methylation can shorten CLS in Saccharomyces cerevisiae. We identified Ubc3/Bre1 mediates polyubiquitination of Set2 K25 and K530 at log phase and stationary phase, and Bre1 interacts with Ubc3 and Rad6 simultaneously. BRE1 knockout can stabilize Set2 protein to maintain H3K36me3 and regulate the transcription of aging related genes, such as DSE1/DSE2/SUN4/EGT2/SCW11. We also proved that Gcn5-mediated Set2 acetylation regulates Set2 protein stability and chronological aging. Altogether, our study showed that knockout of BRE1 and GCN5 regulate Set2 protein level by mediating the polyubiquitination of Set2 to influence the level of H3K36me3 and the transcription level of aging related genes enriched by H3K36me3, thereby extending the chronological life span.

2023-09-29 | GSE221024 | GEO

Bre1-mediated Set2 protein degradation promotes chronological aging in budding yeast [RNA-seq]

2023-09-29 | GSE221025 | GEO

Bre1-mediated Set2 protein degradation promotes chronological aging in budding yeast [RNA-seq]

Project description:Bre1-mediated Set2 protein degradation promotes chronological aging in budding yeast [RNA-seq]

| PRJNA912608 | ENA

Gcn5- and Bre1-mediated Set2 degradation promotes chronological aging of Saccharomyces cerevisiae

Project description:Gcn5- and Bre1-mediated Set2 degradation promotes chronological aging of Saccharomyces cerevisiae

| PRJNA912604 | ENA

Histone H4 acetylation in wild-type, ASF1, SET2 and ASF1 SET2 deletion yeast strains

Project description:ChIP-on chip assays to measure the change in histone acetylation over the yeast genome, in ASF1, SET2 and ASF1 SET2 deletion yeast strains compared to the wild-type control. ChIPs of AcH4 from wild-type, ASF1, SET2 and ASF1 SET2 deletion yeast strains were normalized to the H3 enrichment.

2012-07-25 | GSE28098 | GEO

Gcn5- and Bre1-mediated Set2 degradation promotes chronological aging of Saccharomyces cerevisiae

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-09-29 | GSE221026 | GEO

RNAi in budding yeast

Project description:RNAi in budding yeast

| PRJNA119985 | ENA

DBP1 in budding yeast

Project description:DBP1 in budding yeast

| PRJNA436358 | ENA

Histone acetylation in wild-type and SET2 deletion yeast strains

Project description:ChIP-on chip assays to measure the change in histone acetylation over the yeast genome, in a SET2 deleted strain compared to the wild-type control. ChIPs of H3K9ac, H3K56ac and H4K12ac from wild-type and SET2 deleted cells were normalized to the H3 enrichment.

2012-07-25 | GSE28097 | GEO

Spontaneous mutations in CYC8 and MIG1 suppress the short chronological lifespan of budding yeast lacking SNF1/AMPK

Project description:Spontaneous mutations in CYC8 and MIG1 suppress the short chronological lifespan of budding yeast lacking SNF1/AMPK

| PRJNA433655 | ENA