Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Bulk Omni-ATAC-seq in young (2 months) and aged (22-24 months) mice across 23 cell-types

ABSTRACT: Bulk Omni-ATAC-seq in young (2 months) and aged (22-24 months) mice across 23 cell-types

PROVIDER: PRJNA912643 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22796900_1.fastq.gz	Fastqsanger.gz
	SRR22796900_2.fastq.gz	Fastqsanger.gz
	SRR22797000_1.fastq.gz	Fastqsanger.gz
	SRR22797000_2.fastq.gz	Fastqsanger.gz
	SRR22796901_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 392

Similar Datasets

Bulk Omni-ATAC-seq in young (2 months) and aged (22-24 months) mice across 23 cell-types

Project description:To understand how age rewires the chromatin accessibility landscape, we molecularly profiled 23 purified cell types from 11 tissues and organs by assessing the cumulative signature of 15-25 young and aged mice for robust difference detection.

2024-07-15 | GSE221034 | GEO

Bulk RNA-seq in young (2 months) and aged (22-24 months) mice across 23 cell-types

Project description:Bulk RNA-seq in young (2 months) and aged (22-24 months) mice across 23 cell-types

| PRJNA924765 | ENA

Bulk RNA-seq in young (2 months) and aged (22-24 months) mice across 23 cell-types

2024-07-15 | GSE223049 | GEO

Gene expression profiles in the ileal and colonic epithelial cells from Interleukin (IL)-23-deficient mice and IL-22-deficient mice

Project description:To investigate the function of IL-23 and IL-22 on the intestinal epithelial cells, we analyzed the gene expression profiles in ileal and colonic epithelial cells of mice deficient in IL-23 and IL-22.

2023-09-08 | GSE236445 | GEO

Comparison of age-related changes in gene expression of 2 rat skeletal muscles (20 months, 22 months)

Project description:Comparison of age-related changes in gene expression of 2 rat skeletal muscles (20 months, 22 months)

| PRJNA612539 | ENA

RNA-seq of muscles from young and aged ATF4 mKO mice and littermate controls

Project description:To investigate the roles of ATF4 in skeletal muscle aging we generated muscle-specific ATF4 knockout (ATF4 mKO) mice. We then performed gene expression profiling analysis using data obtained from RNA-seq of tibialis anterior muscles at 6-months and 22-months of age.

2023-05-02 | GSE212675 | GEO

Dcr1-GFP is functional for 22-23 nt small RNAs production

Project description:Dcr1-GFP is functional for 22-23 nt small RNAs production

| PRJNA530697 | ENA

Single cell RNA sequencing of lung myeloid cells from aged (20-22 months old) mice treated with Isotype or anti-IFNAR1 antibody for 1 day or 1 week

Project description:Monocytes and neutrophils are an important subset of myeloid cells in the lung. However, little is known about how aging affects these lung cells, and the role of Type I interferon signaling. Here, we treat aged (20-22 months old) mice with 500ug anti-IFNAR1 antibody (Clone MAR1-5A3 from BioXcell) intraperitoneally (i.p.) once or for 1 week (total 4 i.p. injections, one every other day) and sorted CD45+ CD11b+ Gr1+ cells from the lung the day after the last injection. We performed single cell RNA sequencing to identify the role of Type I Interferon in these cells from the aging mouse lung.

2021-10-20 | GSE167170 | GEO

HTT-OMNI: A Web-based Platform for Huntingtin Interaction Exploration and Multi-omics Data Integration

Project description:We have developed a web-based platform for HTT PPI visualization, exploration, and multi-omic integration called HTT-OMNI. We demonstrate the utility of this platform not only for exploring and filtering existing huntingtin (HTT) PPIs, but also for investigating user-generated omics datasets. For example, we demonstrate the comparison of a published HTT IP-MS experiment, performed in the striatum brain region of a mouse HD model, to unpublished HTT IP-MS experiments in the cortex brain region. Overall, HTT-OMNI summarizes and integrates known HTT PPIs with polyQ-dependent transcriptome and proteome measurements, providing an all-in-one exploratory platform that facilitates the prioritization of target genes that may contribute to HD pathogenesis.

2022-08-15 | PXD034158 | Pride

Transcription profiling of rat heart tissue from animals aged 4 and 22 months

Project description:Myocardial aging leads to a reduction of beta-adrenergic receptor-induced metabolic and contractile responsiveness. We hypothesize that a change in the patterns of gene expression is important in these age-related events. To test this, hearts were harvested from young and aged male rats (3-4 and 20-22 mo, respectively). Total mRNA was extracted and prepared for hybridization to Affymetrix U34A GeneChips. Filtering criteria, involving fold change and a statistical significance cutoff were employed, yielding 263 probe pairs exhibiting differential signals. Of the 163 annotated genes, at least 56 (34%) were classified as signaling/cell communication. Of these 56, approximately half were directly involved in G protein-coupled receptor signaling pathways. We next determined which of these changes might be involved in anti-adrenergic activity and identified 19 potentially important gene products. Importantly, we observed a decrease in beta1-adrenergic receptor and adenylyl cyclase mRNAs, whereas the mRNA encoding beta-arrestin increased. Furthermore, the results demonstrate an increase in mRNAs encoding the adenosine A1 receptor and phospholipase D, which could increase anti-adrenergic effects. Moreover, the mRNAs encoding the muscarinic M3 receptor, nicotinic acetylcholine receptor beta3, and nicotinic acetylcholine receptor-related protein were increased as was the mRNA encoding guanylate kinase-associated protein. Interestingly, we also observed eight mRNAs whose abundance changed three- to sixfold with aging that could be considered as being compensatory. Although these results do not prove causality, they demonstrate that cardiac aging is associated with changes in the profiles of gene expression and that many of these changes may contribute to reduced adrenergic signaling.

2007-10-10 | E-GEOD-421 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data