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Determining the PRDM6 genomic binding sites in primary outflow tract smooth muscle cells

ABSTRACT: Determining the PRDM6 genomic binding sites in primary outflow tract smooth muscle cells

PROVIDER: PRJNA912737 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22753637_1.fastq.gz	Fastqsanger.gz
	SRR22753637_2.fastq.gz	Fastqsanger.gz
	SRR22753638_1.fastq.gz	Fastqsanger.gz
	SRR22753638_2.fastq.gz	Fastqsanger.gz
	SRR22753639_1.fastq.gz	Fastqsanger.gz

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Determining the PRDM6 genomic binding sites in primary outflow tract smooth muscle cells

Project description:Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for PRDM6 in primary outflow tract smooth muscle cells overexpressing FLAG taggged PRDM6

2023-04-12 | GSE221094 | GEO

Effect of smooth muscle specific PRDM6 depletion on Aorta and Ductus Arterious (DA) development

Project description:To investigate the function of PRDM6 in smooth muscle cells during outflow tract development, we have isolated the ascending aorta and the ductus arteriosus (DA) separatly from the E18.5 Wnt1Cre;PRDM6f/f mouse (PRDM6 KO) and PRDM6f/f mouse (Control) and compared the gene expression profile of the four groups of samples

2023-04-12 | GSE221004 | GEO

Investigation of the physiological functions of PRDM6

Project description:PRDM6 belongs to the PRDM family of transcriptional repressors that all contain a PR domain and Zinc finger domains. Prdm6 has transcriptional repressor activity. Prdm6 may regulate factors that are involved in the differentiation / proliferation of smooth muscle cells, promoting proliferation. PRDM6 knockouts are embryonic lethal around 12.0 dpc knockout embryos eventually develop edema: cardiovascular defect vascularization defect in the yolk sac: dysorganized angiogenesis 6 homozygote samples (yolk sacs), age 10.5 days, hybridized against a pool of of 6 wildtype samples in 12 replicates including 6 dye swap experiments.

2010-05-22 | E-GEOD-9065 | biostudies-arrayexpress

Investigation of the physiological functions of PRDM6

Project description:PRDM6 belongs to the PRDM family of transcriptional repressors that all contain a PR domain and Zinc finger domains. Prdm6 has transcriptional repressor activity. Prdm6 may regulate factors that are involved in the differentiation / proliferation of smooth muscle cells, promoting proliferation. PRDM6 knockouts are embryonic lethal around 12.0 dpc knockout embryos eventually develop edema: cardiovascular defect vascularization defect in the yolk sac: dysorganized angiogenesis Keywords: cDNA array, yolk sac, murine embryo E10.5

2008-04-01 | GSE9065 | GEO

Expression data from the neural crest cells isolated from mouse cardiac outflow tract at E10.5

Project description:Neural crest defects lead to congenital heart disease involving outflow tract (OFT) malformation. Integrin-linked-Kinase (ILK) plays important roles in multiple cellular processes and embryogenesis. ILK is expressed in neural crest cells (NCC), but its role in NCC and OFT morphogenesis remains unknown. We used microarrays to detail the global programme of gene expression underlying the morphogenesis of the cardiac neural crest and outflow tract. The outflow tract of control and ILK mutant mouse embryos at E10.5 were dissected and dissociated. Neural crest cells were FACS sorted and used for RNA extraction and hybridization on Affymetrix microarrays.

2012-10-01 | E-GEOD-41179 | biostudies-arrayexpress

Gene expression regionalization in the outflow tract of the mouse heart

Project description:Gene expression profiling of the inferior and superior wall of the distal midgestation arterial domain (outflow tract) of the wild type CD1 mouse embryonic heart

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Deregulation of miRNAs in Infant Outflow Tract Myocardium of Non-syndromic Tetralogy of Fallot

Project description:Tetralogy of Fallot (TOF) is one of the most common heart defects in children and the underlying mechanisms remain elusive. miRNAs are a recently discovered class of regulators of gene expression and are becoming increasingly recognized as important regulators of heart development and function. The objective of the present study was to identify miRNAs that are abnormally expressed in clinical infant outflow tract myocardium tissues of TOFs. Microarray was used to analyze miRNA expression profiles in infant outflow tract myocardium tissues of TOFs and paired normal ones.

2012-08-14 | E-GEOD-40128 | biostudies-arrayexpress

Expression data from the neural crest cells isolated from mouse cardiac outflow tract at E10.5

2012-10-01 | GSE41179 | GEO

An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract

Project description:To identify a functional gene regulatory network that orchestrate transcriptional programs to direct proper outflow tract development, we generated transgenic mice harboring a 226bp-deletion within a GATA-dependent, highly conserved cardiac enhancer region. We then performed gene expression profiling analysis using data obtained from RNA-seq of outflow tract in wildtype and homozygous mutant littermates at embryonic day 12.5.

2023-10-04 | GSE227361 | GEO

Identification of TGF-b targets in the cardiac outflow tract by transcriptomic analysis

Project description:Purpose: identifying, with RNA-seq, genes targets of Alk5 during the development of the cardiac outflow tract in zebrafish. Results: we identified several differential expressed genes, with an enrichment in ECM component genes. As a proof of concept, many TGFb known targets also appeared downregulated.

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