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Transcriptome sequencing analysis of GADD45B and HOPX gene overexpression in human cutaneous melanoma

ABSTRACT: Transcriptome sequencing analysis of GADD45B and HOPX gene overexpression in human cutaneous melanoma

PROVIDER: PRJNA912751 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22756125_1.fastq.gz	Fastqsanger.gz
	SRR22756125_2.fastq.gz	Fastqsanger.gz
	SRR22756126_1.fastq.gz	Fastqsanger.gz
	SRR22756126_2.fastq.gz	Fastqsanger.gz
	SRR22756127_1.fastq.gz	Fastqsanger.gz

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Transcriptome sequencing analysis of GADD45B and HOPX gene overexpression in human cutaneous melanoma

Project description:We first overexpressed two genes, GADD45B and HOPX, in human malignant melanoma cells A375 cells, and then performed transcriptome sequencing. The related differential gene expression and the alteration of related signaling pathways were obtained by comparing with the control group. This study provides a reference and basis for the treatment of human melanoma.

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Overexpression of Gadd45b perturbs DNA methylation in mouse dopaminergic neurons

Project description:Age is a major risk factor for neurodegenerative diseases like Parkinson disease, but few studies have explored the contribution of key hallmarks of aging, namely DNA methylation changes and heterochromatin destructuration, in the neurodegenerative process. Here, we investigated the consequences of viral overexpression of Gadd45b, a multifactorial protein involved in DNA demethylation, in the mouse midbrain. Gadd45b overexpression induced global and stable changes in DNA methylation, particularly in introns of genes related to neuronal functions, as well as on LINE-1 transposable elements. This was paralleled by disorganized heterochromatin, increased DNA damage and vulnerability to oxidative stress. LINE-1 de-repression, a potential source of DNA damage, preceded Gadd45b-induced neurodegeneration, whereas prolonged Gadd45b expression deregulated expression of genes related to heterochromatin maintenance, DNA methylation or Parkinson disease. Our data indicates that aging-related alterations contribute to dopaminergic neuron degeneration with potential implications for Parkinson disease.

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RNA sequencing after HOPX knockdown in human squamous cell carcinoma cell line SCC13

Project description:Cutaneous squamous cell carcinomas (cSCC) are frequent heterogeneous tumours, arising from sun-exposed regions of the skin and characterized by complex pathogenesis. The goals of this study are to investigate the precise role of HOPX in cutaneous SCC development and progression using different approaches, including RNA sequencing analysis in order to find differently expressed genes and signaling pathways altered after HOPX knockdown in cancer cells.

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Overexpression of Gadd45b perturbs DNA methylation in mouse dopaminergic neurons

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Persistence of effector memory Th1 cells is regulated by the homeobox only protein Group1 Hopx-/-, Group2 Hopx+/-, Group3 Hopx+/+

Project description:Hopx appears to be needed for persistence of Th1 effector memory cells. IFN-gamma-producing Th cells are significantly reduced in Hopx-deficient mice compared to Hopx-expressing littermates and Hopx-deficient Th1 cells show a defective persistence upon adoptive transfer. Moreover, Hopx protects Th1 cells from Fas-mediated cell death in vitro. To further dissect the role of Hopx and to identify target genes of Hopx, we have performed transcriptome analysis to compare gene expression in Hopx-deficient versus Hopx-competent Th1 cells. In agreement with the role of Hopx in supporting survival of Th1 effector memory cells, anti-apoptotic cells were up-regulated and pro-apoptotic genes were down-regulated in Hopx-competent compared to Hopx-deficient Th1 cells.

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