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Serpine1 functions as a non-coding RNA regulating post-transcriptionally epithelial mesenchymal transition [iCLIP]

ABSTRACT: Serpine1 functions as a non-coding RNA regulating post-transcriptionally epithelial mesenchymal transition [iCLIP]

PROVIDER: PRJNA913121 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22765778.fastq.gz	Fastqsanger.gz
	SRR22765779.fastq.gz	Fastqsanger.gz
	SRR22765780.fastq.gz	Fastqsanger.gz
	SRR22765781.fastq.gz	Fastqsanger.gz
	SRR22765782.fastq.gz	Fastqsanger.gz

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Serpine1 functions as a non-coding RNA regulating post-transcriptionally epithelial mesenchymal transition [iCLIP]

Project description:Serpine1 mRNA is abundantly induced during EMT. Paradoxically, this mRNA is enriched in the RISC complex, blocking its translation and acting as an endogenous RNA competitor for several miRNAs. Cells that overexpress Serpine1 mRNA have a greater capacity for migration, invasiveness, and resistance to anoikis. These cells show an altered proteomic profile, highlighting the increased levels of expression of the splicing factor TRA2b. This splicing factor is posttranscriptionally regulated during EMT by upregulation of Serpine1 mRNA and the resulting sequestration of miR-130b-5p by this mRNA, which contains three binding sites for miR-130b-5p. Through transcriptomic analysis, we confirmed that Serpin 1 mRNA expression modulates the expression of numerous genes, most of which (>60%) are also modulated by TRA2b overexpression.

2023-12-15 | GSE221152 | GEO

Serpine1 functions as a non-coding RNA regulating post-transcriptionally epithelial mesenchymal transition [RNA-seq]

2023-12-15 | GSE221076 | GEO

Serpine1 functions as a non-coding RNA regulating post-transcriptionally epithelial mesenchymal transition

Project description:Serpine1 functions as a non-coding RNA regulating post-transcriptionally epithelial mesenchymal transition

| PRJNA913119 | ENA

Serpine1 functions as a non-coding RNA regulating post-transcriptionally epithelial mesenchymal transition [RNA-seq]

Project description:Serpine1 functions as a non-coding RNA regulating post-transcriptionally epithelial mesenchymal transition [RNA-seq]

| PRJNA912707 | ENA

Serpine1 functions as a non-coding RNA regulating post-transcriptionally epithelial mesenchymal transition

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-12-15 | GSE221153 | GEO

Transcriptome sequencing of Serpine1-overexpression MLE-12 cells

Project description:To determine the function of Serpine1 in alveolar cells, the Serpine1 overexpression plasmid pCI-neo-Serpine1 was constructed and transfected into MLE-12 cells

2022-10-05 | GSE212689 | GEO

SM004 - SARS infection of C57BL6, TIMP1 and Serpine1 knock-out mice.

Project description:This purpose of this experiment was to investigate the transcriptional differences between C57BL6, TIMP1 and Serpine1 knock-out mice infected with SARS MA15 virus. Overview of Experiment: Groups of 20 week old C57BL6, TIMP1 and Serpine1 (PAI1) knock-out mice were infected with SARS MA15 virus. Infections were done at 10^4 PFU or time-matched mock infected. Time points were 4 and 7 d.p.i. There were 2-4 animals/dose/time point. Lung samples were collected for virus load, transcriptional and proteomics analysis. Weight loss and animal survival were also monitored.

2014-02-20 | E-GEOD-51386 | biostudies-arrayexpress

eIFA3 - iCLIP

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