Project description:Gene expression profile at single cell level of CD45+ cells isolated from wildtype (twi littermate) mouse brain (postnatal day 21) to evaluate and compare differences in immune cells at the onset of spontaneous clinical disease in a mouse model of globoid cell leukodystrophy.
Project description:To understand the function of CD25/IL-2Ra in the regulation of alopecia development, we sorted live CD45 + and CD45- population from the skin of Up_del mice and were subjected to single-cell RNA-sequencing.
Project description:To obtain a large representation of non-immune skin-resident cells, we profiled CD45-negative cells from a digested skin sample taken from a human female