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Yeast Lachancea Kluyveri uses tripartite mechanism for haploid specific gene repression [ChIP-seq]

ABSTRACT: Yeast Lachancea Kluyveri uses tripartite mechanism for haploid specific gene repression [ChIP-seq]

PROVIDER: PRJNA916270 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22903643.fastq.gz	Fastqsanger.gz
	SRR22903644.fastq.gz	Fastqsanger.gz
	SRR22903645.fastq.gz	Fastqsanger.gz
	SRR22903646.fastq.gz	Fastqsanger.gz
	SRR22903647.fastq.gz	Fastqsanger.gz

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Yeast Lachancea Kluyveri uses tripartite mechanism for haploid specific gene repression.

Project description:Yeast Lachancea Kluyveri uses tripartite mechanism for haploid specific gene repression.

| PRJNA916669 | ENA

Yeast Lachancea Kluyveri uses tripartite mechanism for haploid specific gene repression [RNA-seq]

Project description:Yeast Lachancea Kluyveri uses tripartite mechanism for haploid specific gene repression [RNA-seq]

| PRJNA916672 | ENA

Yeast Lachancea Kluyveri uses tripartite mechanism for haploid specific gene repression [ChIP-seq]

Project description:Over evolutionary timescales, the logic and pattern of cell-type specific gene expression can remain constant, yet the molecular mechanisms underlying such regulation can drift between alternative forms. Here, we document a new, especially clear example of this principle in the regulation of the haploid-specific genes across a wide group of fungal species. For most species, transcription of these genes is repressed in the a/ a cell type by a heterodimer of two homeodomain proteins, Mata1 and Mata2. We show that in the species Lachancea kluveri, repression of one haploid-specific gene (GPA1) requires, in addition to Mata1 and Mata2, a third regulatory protein, Mcm1. Model building, based on x-ray crystal structures of the three proteins, rationalizes the requirement for all three proteins: no single pair of the proteins is optimally arranged and we show that no single pair can bring about repression. Although the three-part solution is used to regulate GPA1 in L. kluveri, the other haploid specific genes in this species are regulated by the more conventional two-protein mechanism. This case study exemplifies the idea that the energy of DNA binding can be “shared out” in different ways and can result is different DNA-binding solutions across different genes—while maintaining the same pattern of gene expression.

2023-02-22 | GSE221835 | GEO

Yeast Lachancea Kluyveri uses tripartite mechanism for haploid specific gene repression [RNA-seq]

2023-02-22 | GSE221890 | GEO

Iron-responsive genes in Lachancea kluyveri

Project description:To understand the iron-responsive gene expression in Lachancea kluyveri under high and low iron conditions, we perfomred the genome-wide gene expression profiling for the log-phase cells of Lachancea kluyveri wild type, sef1 deletion, aft1 deletion and sef1aft1 double deletion mutants under the YPD+400mM ferrous iron and YPD+ 200 mM BPS conditions.

2019-04-26 | GSE130296 | GEO

Sef1-dependent gene expression in Lachancea kluyveri

Project description:To understand the Sef1-dependent gene expression in Lachancea kluyveri under both fermentative and respiratory conditions, we perfomred the genome-wide gene expression profiling for the log-phase cells of Lachancea kluyveri wild type and sef1 deletion mutant under both YPD and YPGly conditions.

2019-04-26 | GSE130297 | GEO

S-phase time-course of Lachancea kluyveri cells

Project description:Haploid cells of Lachancea kluyveri were arrested in G1 phase using Saccharomices cerevisiae alpha factor. After, release in a new media, cells go synchronously through S-phase. One sample is taken every five minutes. Microarrays are used to monitor the change of DNA copy number from 1 to 2, all along the genome during S-phase.

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Sef1-VP16 dependent gene expression in Lachancea kluyveri

Project description:To understand the highly active Sef1-VP16 dependent gene expression in Lachancea kluyveri under both fermentative and respiratory conditions, we perfomred the genome-wide gene expression profiling for the log-phase cells of Lachancea kluyveri wild type and SEF1-VP16 gain-of-function mutant under both YPD and YPGly conditions.

2019-04-26 | GSE130300 | GEO

S-phase time-course of Lachancea kluyveri cells

2013-02-01 | E-GEOD-37244 | biostudies-arrayexpress

Lachancea kluyveri (formerly Saccharomyces kluyveri); Growth on different nitrogen sources.

Project description:Transcriptional profiling of the yeast Lachancea kluyveri when grown on minimal media with different compounds added as the sole nitrogen source. Cells grown on uracil, uridine, dihydrouracil and ammonia were profiled using cells grown on proline as the reference.

2013-06-21 | GSE48135 | GEO

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