Project description:The intrinsic regulators of stem cell-based embryo models are not well studied. We show that Nr1h2 activation enables conventional ESCs to form blastoids with better implantation and higher blastocyst rates. We identified Nr1h2 transcriptional interactome by CoIP-MS using FLAG antibody to immunoprecipitate Nr1h2-FLAG and its partners in ESC overexpressing Nr1h2-FLAG.

2024-10-28 | PXD057257 | Pride

Mdivi-1 treatment regulates embryo epigenome

Project description:We mouse early embryos with Mdivi-1 and exmained changes of embryo epigenome.

2023-05-05 | GSE221887 | GEO

Microarray expression data following the treatment of mouse ESC with Panobinostat/LBH589

Project description:Microarray expression data following the treatment of mouse ESC with Panobinostat/LBH589

| PRJNA562880 | ENA

Lactate treatment regulates epigenome of mouse embryonic stem cells (mESCs)

Project description:We treated mESCs with 50mM lactate to examine its impact on mESC epigenome. Interestingly, we found that lactate supplementation stimulated H3K18 lactylation accumulation on a subset of genes, which in turn promoted transcriptional elongation. Our results indicate that lactate supplementation expands transcriptional network of mouse ESCs.

2022-02-01 | GSE192358 | GEO

Novel DNA modification in mouse ESC

Project description:Novel DNA modification in mouse ESC

| PRJNA292541 | ENA

RNA-seq for siNr1h2 in mouse blastoid samples and T0901317-treatment in mouse ESC and EPSC

Project description:RNA-seq for siNr1h2 in mouse blastoid samples and T0901317-treatment in mouse ESC and EPSC

| PRJNA867550 | ENA

Maternal Smchd1 regulates Hox gene expression and patterning in the mouse embryo [ESC RRBS]

Project description:Maternal Smchd1 regulates Hox gene expression and patterning in the mouse embryo [ESC RRBS]

| PRJNA841596 | ENA