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Gene expression signatures of megakaryocytes post-IR

ABSTRACT: Gene expression signatures of megakaryocytes post-IR

PROVIDER: PRJNA922441 | ENA |

REPOSITORIES: ENA

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Gene expression signatures of megakaryocytes post-IR

Project description:Platelets are anucleated blood cells that are produced by their progenitor cell, the megakaryocyte (MK). Platelets are centrally positioned in hemostasis and thrombosis and, according to the recent findings, play key roles in innate immunity, inflammation, atherogenesis, and cancer metastasis. The quantitative and qualitative properties of platelets are crucial determinants of their hemostatic function. While the regulatory mechanisms of platelet number and size have been studied separately, critical questions remain regarding the interplay of platelet number and size in hemostasis. In this study, using a mouse model of irradiation (IR)-induced thrombocytopenia, we show that mature MKs (mMKs) are resistant to IR and maintain the nadir platelet levels post IR. To identify the phenotype switching and function variation in BM MKs post IR, we performed microarray expression profiling of MKs from the bone marrow of mice at 1- or 3-days post IR and control mice (Ctrl).

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Gene expressioin signatures in human lymphoblastoid cell lines with different ataxia telangiectasia-mutated (ATM) genotypes post sham- or IR-treatment

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Project description:Gene expression profiles of cultured megakaryocytes

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Expression data from macrophages sorted from the heart tissue of WT mice post-IR

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Development of gene expression signatures for lenalidomide treatement on megakaryocyte

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