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Interfering with glycolysis potentiates the long-term effect of local tumor ablation via CD8+TCM cell differentiation [MWA or MWA+2DG group]

ABSTRACT: Interfering with glycolysis potentiates the long-term effect of local tumor ablation via CD8+TCM cell differentiation [MWA or MWA+2DG group]

PROVIDER: PRJNA922757 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23047957_1.fastq.gz	Fastqsanger.gz
	SRR23047957_2.fastq.gz	Fastqsanger.gz
	SRR23047958_1.fastq.gz	Fastqsanger.gz
	SRR23047958_2.fastq.gz	Fastqsanger.gz
	SRR23047959_1.fastq.gz	Fastqsanger.gz

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Interfering with glycolysis potentiates the long-term effect of local tumor ablation via CD8+TCM cell differentiation [MWA+PBS or MWA+2DG]

Project description:Interfering with glycolysis potentiates the long-term effect of local tumor ablation via CD8+TCM cell differentiation [MWA+PBS or MWA+2DG]

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Interfering with glycolysis potentiates the long-term effect of local tumor ablation via CD8+TCM cell differentiation [MWA or MWA+2DG group]

Project description:To evaluate the immune responses in tumor-draining lymph nodes induced by microwave ablation (MWA) or microwave ablation combined with 2DG (MWA+2DG), we then performed gene expression profiling analysis using data obtained from RNA-seq of 5 different lymph nodes from two group of mice.

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Interfering with glycolysis potentiates the long-term effect of local tumor ablation via CD8+TCM cell differentiation [MWA+PBS or MWA+2DG]

Project description:To evaluate the genetic changes of systemic CD8+T cells induced by microwave ablation(MWA+PBS) or microwave ablation combined with 2DG(MWA+2DG),We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 different spleens from two group of mice.

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Interfering with glycolysis potentiates the long-term effect of local tumor ablation via CD8+TCM cell differentiation

Project description:Interfering with glycolysis potentiates the long-term effect of local tumor ablation via CD8+TCM cell differentiation

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Combinatorial targeting of glycolysis and oxidative phosphorylation suppresses tumor growth and metastases.

Project description:The Warburg effect, consisting of increased glucose uptake and glycolysis, provides metabolic energy as well as cellular building blocks for tumor growth. Inhibition of the Warburg effect with 2-deoxyglucose (2DG) has been explored in clinical trials with limited efficacy. Blockage of glycolysis can induce autopahgy resulting in alternative energy generation through oxidative phosphorylation providing a potential bypass of the effects of inhibition of glycolysis. Here in we demonstrate that activation of AMPK, as a consequence of energetic stress, induces mitochondrial energy production potentially bypassing the effects of glycolysis inhibition. We thus combined blockage of glycolysis by 2DG with inhibition of the electron transfer complex I (ETC1) in the mitochondria with the clinically applicable antidiabetic drug metformin. The combination resulted in activation of AMPK and autopahgy that however rendered eventual depletion of ATP and cell death. Furthermore, combined inhibition of glycolysis and mitochondrial respiration inhibited tumor growth and markedly decreased metastatic capacity in vivo. In order to understand the mechanism of these metabolic inhibitors, we performed whole genome transcriptional analysis. Human SK-4 esophageal cancer cell lines were treated with 5 different treatment groups [2 deoxy glucose (4mM), Metformin (5mM), AICAR (2mM), 2 deoxy glucose (4mM) plus Metformin (5mM) and 2 deoxy glucose (4mM) plus AICAR (2mM)] with non treated control groups for 12 hrs. Each groups was quadruplicated. Microarray experiments and data analysis were done at Dept. of Systems Biology, MDACC (Houston, USA)

2012-12-31 | E-GEOD-16816 | biostudies-arrayexpress

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Interfering with glycolysis potentiates the long-term effect of local tumor ablation via CD8+TCM cell differentiation

Project description:This SuperSeries is composed of the SubSeries listed below.

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Combinatorial targeting of glycolysis and oxidative phosphorylation suppresses tumor growth and metastases.

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