Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Neutrophil metalloproteinase driven spleen architecture breakdown hampers plasma cell generation and infection control of trypanosomiasis.

ABSTRACT: Neutrophil metalloproteinase driven spleen architecture breakdown hampers plasma cell generation and infection control of trypanosomiasis.

PROVIDER: PRJNA923367 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23071288.fastq.gz	Fastqsanger.gz
	SRR23071289.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

Neutrophil metalloproteinase driven spleen architecture breakdown hampers plasma cell generation and infection control of trypanosomiasis.

2023-08-10 | GSE222784 | GEO

Neutrophil metalloproteinase driven spleen damage hampers infection control of trypanosomiasis.

Project description:Recent blood transcriptomic analysis of rhodesiense sleeping sickness patients has revealed that neutrophil signature genes and activation markers constitute the top indicators of trypanosomiasis-associated inflammation. Here, we show that Trypanosoma brucei infection results in expansion and differentiation of four splenic neutrophil subpopulations, including Mki67+Birc5+Gfi1+Cebpe+ proliferation-competent precursors, two intermediate immature subpopulations and Cebpb+Spi1+Irf7+Mcl1+Csf3r+ inflammation reprogrammed mature neutrophils. Transcriptomic scRNA-seq profiling identified the largest immature subpopulation by Mmp8/9 positive tertiary granule markers. We confirmed the presence of both metalloproteinases in extracellular spleen homogenates and plasma. During infection, these enzymes digest extracellular matrix components in the absence of sufficient TIMP inhibitory activity, driving remodeling of the spleen follicular architecture. Neutrophil depletion prevents the occurrence of organ damage, resulting in increased plasma cell numbers and prolonged host survival. We conclude that trypanosomiasis-associated neutrophil activation is a major contributor to the destruction of the secondary lymphoid architecture, required for maintaining an efficient adaptive immune response.

| S-EPMC10480172 | biostudies-literature

Functional evaluation of neutrophil of patients at high risk for infection treated with monocyte/ neutrophil apheresis

Project description:Interventions: monocyte/neutrophil apheresis non monocyte/neutrophil apheresis Primary outcome(s): Evaluation neutrophil function of patients at high risk for postoperative infection treated with monocyte/neutrophil apheresis Study Design: Parallel Non-randomized

| 2627605 | ecrin-mdr-crc

Functional evaluation of neutrophil of patients at high risk for infection treated with multiple monocyte/ neutrophil aphaereses

Project description:Interventions: multiple monocyte/neutrophil apheresis non monocyte/neutrophil apheresis Primary outcome(s): Evaluation neutrophil function of patients at high risk for postoperative infection treated with monocyte/neutrophil apheresis Study Design: Parallel Non-randomized

| 2628620 | ecrin-mdr-crc

Matrix metalloproteinase-3 mediates cardiac differentiation of mouse embryonic stem cells

Project description:Recently, it was shown that the Bmp antagonist Noggin could strongly induce cardiomyocyte differentiation by transient treatment of undifferentiated ES cells. In order to determine how Noggin may induce cardiac differentiation, we compared differentially expressed genes during Noggin treatment of ES cells using microarray analysis and found that matrix metalloproteinase (Mmp)-3 is the only gene whose expression is increased by Noggin treatment. Keywords: embryonic stem cells, cardiac differentiation, matrix metalloproteinase-3, Noggin

2007-12-18 | GSE8328 | GEO

Peripheral immune-derived matrix metalloproteinase promotes stress susceptibility

Project description:Peripheral immune-derived matrix metalloproteinase promotes stress susceptibility

| PRJNA836902 | ENA

Dystrophin deficiency hampers cell state transitions during somite development

Project description:Dystrophin deficiency hampers cell state transitions during somite development

| PRJNA976739 | ENA

Tissue neutrophil heterogeneity

Project description:Tissue neutrophil heterogeneity

| PRJNA594618 | ENA

The alarmin S100A9 hampers retroviral infection by limiting reverse transcription

Project description:The alarmin S100A9 hampers retroviral infection by limiting reverse transcription