Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Profiles and key drivers of bacteria/phage co-mediated antibiotic resistance genes during swine manure composting amended with humic acid

PROVIDER: PRJNA923633 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23088568_1.fastq.gz	Fastqsanger.gz
	SRR23088568_2.fastq.gz	Fastqsanger.gz
	SRR23088569_1.fastq.gz	Fastqsanger.gz
	SRR23088569_2.fastq.gz	Fastqsanger.gz
	SRR23088570_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 26

Similar Datasets

Project description:Swine manure composting

| PRJNA1119286 | ENA

Project description:Swine manure composting

| PRJNA714270 | ENA

Project description:Swine manure composting

| PRJNA1036415 | ENA

swine manure composting

Project description:swine manure composting Raw sequence reads

| PRJNA640977 | ENA

Project description:Investigating lignocellulose degradation and humic substance during cotton straw and cow manure co-composting

| PRJNA1197777 | ENA

Project description:Swine manure composting sample 16S rRNA sequencing

| PRJNA663659 | ENA

microbiome

Project description:Microbiome in swine manure composting Genome sequencing and assembly

| PRJNA892010 | ENA

Rapid design of bacteriophage cocktails to suppress the burden and virulence of gut-resident carbapenem-resistant Klebsiella pneumoniae

Project description:Antibiotic use can lead to expansion of multi-drug resistant pathobionts within the gut microbiome that can cause life-threatening infections. Selective alternatives to conventional antibiotics are in dire need. Here, we describe a Klebsiella PhageBank that enables the rapid design of antimicrobial bacteriophage cocktails to treat multi-drug resistant Klebsiella pneumoniae. Using a transposon library in carbapenem-resistant K. pneumoniae, we identified host factors required for phage infection in major Klebsiella phage families. Leveraging the diversity of the PhageBank and experimental evolution strategies, we formulated combinations of phages that minimize the occurrence of phage resistance in vitro. Optimized bacteriophage cocktails selectively suppressed the burden of multi-drug resistant K. pneumoniae in the mouse gut microbiome and drove bacterial populations to lose key virulence factors that act as phage receptors. Further, phage-mediated diversification of bacterial populations in the gut enabled co-evolution of phage variants with higher virulence and a broader host range. Altogether, the Klebsiella PhageBank represents a roadmap for both phage researchers and clinicians to enable phage therapy against a critical multidrug-resistant human pathogen.

2024-10-01 | GSE272297 | GEO

biogas co-fermentation

Project description:anaerobic co-fermentation of straw and swine manure

| PRJEB4791 | ENA

Project description:Bacterial community structure changes of swine manure composting by electrokinetic remediation

| PRJNA1009993 | ENA